Hightop-Pin Tablets (Esamlodipine Nicotinic Acid Salt)

Adult dose

As esamlodipine, it is taken orally at 2.5mg once daily, and the dose may be increased up to a maximum of 5mg per day according to the patient's response. Adjustments should be made according to symptoms. This medication should be taken with a sufficient amount of water.

Child dose

The recommended oral dosing of esamlodipine for effective blood pressure reduction is 1.25mg-2.5mg once daily. Doses exceeding 2.5mg per day have not been studied in pediatric patients. This medication is to be taken with a sufficient amount.

It is very important not to use this medication in certain patients. It should not be administered to patients who are allergic to this medicine or its components or have had hypersensitivity reactions to similar medications. Furthermore, it should not be used in nursing women, patients with cardiogenic shock, severe aortic stenosis, unstable angina, recent myocardial infarction patients, or those with severe liver dysfunction or hypotension. There are also patients who should be cautious when using this medication. For example, patients with severely impaired renal function, elderly individuals, acute heart failure patients, those in hypertensive crisis, patients with mildly impaired liver function, and women who are pregnant or may become pregnant should use this medication carefully. This medicine generally has good tolerability, but it may cause flushing or a sensation of warmth, fatigue, swelling, palpitations, dizziness, headaches, dyspepsia, drowsiness, edema of the ankles, etc. Rarely, dry mouth, increased sweating, hypotension, syncope, sensory disturbances, erectile dysfunction, and liver dysfunction may occur. Abrupt discontinuation of this medication may worsen symptoms, so the dosage should be gradually reduced under a doctor's guidance, and care should be taken not to stop taking it arbitrarily. Additionally, patients with poor liver function may experience prolonged effects from this medication, so caution is required. It is advisable to take this medication with a sufficient amount of water, and as blood pressure may drop causing dizziness, caution should be exercised when driving or operating dangerous machinery. This medication may interact with several other drugs, so if you are taking any other medications, be sure to inform your doctor or pharmacist. In particular, taking it with grapefruit juice may enhance the blood pressure-lowering effect, so it is advisable to avoid it. Women who are pregnant or nursing should consult their doctor before using this medication, and if nursing, it is recommended to stop breastfeeding. For children, it is recommended only for those 6 years and older, as safety and efficacy for children under 6 years of age have not been established. Elderly individuals may have higher body concentrations of the drug, and the effects may last longer, so start with a lower dosage and administer carefully. In case of overdose, severe hypotension, headaches, and cardiac abnormalities may occur, so immediate consultation with a medical institution is necessary to receive appropriate treatment. This medicine should be stored in a place inaccessible to children and should preferably not be transferred to another container.

Serious side effects

• Hives
• angioedema
• toxic epidermal necrolysis
• jaundice
• paralysis

Mild side effects

• Flushing with warmth
• fatigue
• swelling
• palpitations
• dizziness
• headache
• migraine
• weakness
• abdominal pain
• nausea

This medication should be stored in a tightly closed container that is not exposed to air or moisture, and the storage temperature should be maintained between 1 and 30 degrees Celsius. Storing it this way helps to maintain the medication's effectiveness for a long time.

Appearance

White pentagonal tablet

Package unit

30 tablets/box [(10 tablets/PTP x 3)], 30 tablets/bottle, 300 tablets/bottle