Aprovel Tablets 300 mg (Irbesartan)

Adult dose

For adults with essential hypertension, administer 150 mg of Irbesartan orally once daily, and if the effect is insufficient, it can be increased to 300 mg. For adults with kidney disease and hypertension who have type 2 diabetes, it is recommended to start with 150 mg orally once daily and increase up to 300 mg for maintenance. In elderly patients (aged 75 and over) and patients on dialysis, an initial dose of 75 mg should be considered.

This medication can cause serious harm, particularly to the fetus and newborn, during pregnancy; therefore, it should be discontinued immediately if pregnancy is confirmed. This medication should not be used by women who are pregnant, breastfeeding, or patients with severe liver disease or allergies to this drug or its components. Particularly, patients with a history of angioedema, certain hereditary metabolic disorders, diabetic nephropathy patients, and those taking ACE inhibitors should avoid administration. Elderly patients, those with hyperkalemia, liver disease, and heart disease should use this medication cautiously, as there is a risk of blood pressure dropping too low, requiring attention. This medication generally has many mild side effects, with the most common being upper respiratory infection, headache, muscle pain, dizziness, and fatigue. Rarely, serious adverse reactions such as angioedema, hyperkalemia, renal failure, liver function impairment, hypoglycemia, or rhabdomyolysis may occur, so consult a doctor immediately if unusual symptoms develop. While taking this medication, regular checks of blood pressure, kidney function, and blood potassium levels are essential. Patients with poor kidney or heart function should be particularly cautious. Interactions may occur when combined with other antihypertensives, diuretics, potassium-sparing agents, lithium, and non-steroidal anti-inflammatory drugs (NSAIDs), so always consult healthcare providers. Use during pregnancy is prohibited, and if breastfeeding, either the administration should be avoided, or nursing should be discontinued as this medication can pass into breast milk. Safety in children has not been established, so it is best not to use it in pediatric patients. In cases of overdose, symptoms such as hypotension, tachycardia, and bradycardia may occur; immediate medical attention should be sought if symptoms develop. This medication should be stored out of the reach of children, and it is safest to keep it in its original container. Dizziness or fatigue may occur upon administration, so caution is advised when driving or operating machinery. Patients undergoing diabetes treatment must be vigilant for the risk of hypoglycemia and may require adjustments in drug dosage.

Serious side effects

Hives, severe swelling (edema), angioedema, chest tightness, difficulty breathing, cold sweat, pallor, severe allergic reactions, severe rash with fever, blisters, skin peeling, pain in mucous membranes of the mouth/eyes, severe skin reactions, shortness of breath or difficulty breathing, asthma attacks, respiratory issues with cough and fever, skin or eye jaundice (yellowing), profound fatigue, liver impairment (jaundice)

Mild side effects

• Upper respiratory infection
• sinusitis
• influenza
• pharyngitis
• rhinitis
• musculoskeletal pain
• muscle pain
• headache
• dizziness
• fatigue

This medication should be stored in a tightly sealed container to prevent air or moisture from entering. It is also advisable to keep it in a dry place below 30 degrees Celsius. Proper storage can help maintain the efficacy of the medication over time.

Appearance

Oval, film-coated tablets that are white or almost white, biconvex on both sides with a heart shape engraved on one side and the number "2873" engraved on the other side.

Package unit

30 tablets (10 tablets/blister × 3), 100 tablets/bottle