Hyaluronic Acid Inj. (Sodium Hyaluronate) (Pre-filled)

Adult administration

Administer 25mg weekly for 5 weeks as sodium hyaluronate into the intra-articular space of the knee joint or shoulder joint (shoulder joint cavity, subacromial bursa, or bicipital tendon sheath). Adjust the frequency of administration according to symptoms. Since it is administered intra-articularly, it should be performed under strict aseptic conditions.

This medicine should not be used in patients who have had allergic reactions to this drug or any of its ingredients. Since it is injected into the joint, it is safe not to administer if there are skin conditions or infections at the injection site. Patients with liver dysfunction or a history of liver disease should consult a healthcare professional before using this medicine. During administration, serious allergic reactions, such as shock, may occur, so careful monitoring is necessary, and if any unusual symptoms arise, administration should be stopped immediately, and appropriate treatment sought. Hypersensitivity reactions such as swelling, facial flushing, rash, hives, and itching may occur, so these symptoms should prompt stopping use and informing a healthcare professional. Temporary pain, swelling, redness, warmth, severe tenderness, and bruising at the injection site may occur, so these symptoms should be anticipated. Common side effects such as nausea, vomiting, fever, and headaches may also occur, and if symptoms are severe, consultation with a physician is recommended. Administering this drug to inflamed joints may worsen the inflammation, so it is advisable to use it after inflammation has subsided. After injection, it is important to stabilize the injection site and avoid strenuous exercise or activities that put stress on the joint. If the drug leaks outside the joint, it may cause pain, so it must be injected accurately into the joint. Inflammatory joint disease patients with rheumatoid arthritis or gouty arthritis may experience a temporary increase in inflammation; caution is advised. For 48 hours after administration, activities such as jogging, tennis, or prolonged weight-bearing should be avoided. When using with other intra-articular injectables, safety and efficacy have not been confirmed, so it is recommended not to combine them. Pregnant women or those who could become pregnant should cautiously use this medicine only if the benefits outweigh the risks, as its effects on the fetus are not fully understood. Nursing mothers should avoid breastfeeding during treatment, as this medicine could be passed through breast milk. The safety for children has not been adequately established, so caution should be exercised only for essential use. Elderly patients may have decreased bodily function, so special care should be taken during administration. Aseptic conditions must be maintained during injection to minimize the risk of infection, and if symptoms do not improve, administration should be limited to a maximum of 5 times. If there is a large amount of joint fluid, it is advisable to remove it before injection. This medicine is not suitable for intravenous administration or for use in the eyes. Due to its high viscosity, it is important to use appropriately sized needles when drawing the solution into the syringe and when administering the injection. There may be residue on the top part of the ampoule, so before injecting, the ampoule should be shaken well to allow the solution to flow downward and then carefully aspirated. When cutting the ampoule, it is safest to clean it with a sterile cloth to avoid contaminating it. Caution is required as mixing with disinfectants such as benzalkonium chloride or chlorhexidine may cause precipitation. This medicine is for single use only; any unused portion should be discarded immediately after opening.

Serious side effects

• Urticaria
• swelling (facial, eyelid, etc.)
• shock (hypersensitivity reaction)

Mild side effects

• Facial flushing
• rash
• itching
• transient pain
• swelling
• edema
• redness
• warmth
• severe local tenderness
• petechiae

This medicine should be stored in a sealed container to prevent air or moisture from entering. It is important to maintain a storage temperature between 1 to 30 degrees Celsius to preserve the effectiveness and safety of the medicine.

Appearance

A colorless, transparent viscous liquid filled in a glass or plastic tube sealed with rubber stoppers at both ends (part of the pre-filled syringe system).

Package unit

2.5mL/tube X 5