Actim Tablet (Pioglitazone Hydrochloride)

Adult dose

This medication is taken orally once daily, regardless of meals. The initial monotherapy dosage can be started at 15 mg once daily, and if the effect is insufficient, it can be increased to 30 mg once daily. For combination therapy with sulfonylureas, metformin, or insulin, the initial dose is 15 mg once daily, with a maximum recommended dose not exceeding 30 mg once daily.

Child dose

Use in children under 18 years of age is not recommended due to lack of experience.

This medication is used in the treatment of type 2 diabetes and works to improve insulin resistance. When taking this medication, care must be taken with cardiac function. This medication should be avoided in patients with congestive heart failure, as it may worsen the condition. After starting treatment, the physician should closely monitor for signs of heart failure, such as weight gain, shortness of breath, and swelling. This medication should not be used in patients with a history of heart failure, active bladder cancer, or severe liver or kidney dysfunction. Additionally, women who are pregnant or may become pregnant should exercise caution when taking this medication and should use appropriate contraception. This medication may cause fluid retention and edema, so it should be used cautiously in patients with edema, and consultation with a physician should occur if edema worsens. The risk of hypoglycemia may increase when used in combination with insulin or other hypoglycemic agents such as sulfonylureas, so blood sugar levels and symptoms of hypoglycemia should be closely monitored during combination therapy. Regular liver function tests should be conducted in patients with liver function abnormalities, and any symptoms suggestive of liver damage should be reported to healthcare providers immediately. Long-term use of this medication may increase the risk of weight gain and fractures, making it crucial to periodically assess weight and bone health status. If gross hematuria or urinary dysfunction occurs during use, there is a possibility of bladder cancer, so the doctor should be informed immediately. The safety and efficacy of this medication in children or individuals under 18 years of age have not been established. This medication can interact with other drugs, so it is essential to inform healthcare providers of any other medications being taken. In case of overdose, specific symptoms may not be present, but appropriate treatment should be pursued according to the symptoms.

Serious side effects

Congestive heart failure, symptoms and signs of heart failure (excessive and rapid weight changes, shortness of breath, swelling), edema (peripheral edema, generalized edema, pitting edema, and fluid retention), gross hematuria, urinary dysfunction, urgency, bladder cancer, liver failure, abnormal liver function test results (ALT or total bilirubin levels exceeding three times the upper limit of normal), jaundice, macular edema, severe allergic reactions (hives, severe swelling, chest tightness,

Mild side effects

• Upper respiratory infection
• headache
• sinusitis
• myalgia
• pharyngitis
• abdominal bloating
• weight gain
• hypoglycemia
• urinary tract infection
• back pain

This medication should be stored in a container that does not allow light and air ingress, and it should be kept away from humid places. The recommended storage temperature is between 15°C and 30°C, and it is best stored at room temperature around 25°C.

Appearance

White to grayish round tablets

Package unit

30 tablets/bottle, 100 tablets/bottle