Pactos Tablet (Pioglitazone Hydrochloride)

Adult dose

This medication is taken orally once daily, regardless of meals. Monotherapy: It can be started at a dose of 15 mg once daily, and if the effect is insufficient, it can be increased up to 30 mg once daily. Combination therapy: 1) When used in combination with sulfonylureas, an initial dose of 15 mg once daily is recommended. 2) When used in combination with metformin, an initial dose of 15 mg once daily is recommended. 3) When used in combination with insulin, the initial dose is 15 mg once daily.

Child dose

There is no experience in children under the age of 18, so use is not recommended.

This medication may cause or worsen heart failure in some patients; therefore, after starting treatment or increasing the dosage, careful monitoring for symptoms such as weight changes, shortness of breath, and edema is necessary. Patients with heart failure or a history of heart failure should not use this medication and should seek immediate consultation if symptoms arise. This medication may cause fluid retention, which can worsen heart failure; therefore, it should be used with caution in patients with cardiovascular disease. Patients with bladder cancer or a history of bladder cancer should not take this medication, and if symptoms such as hematuria or urinary disturbances occur during treatment, they should inform their physician immediately. Patients with impaired liver function or severe renal impairment should also avoid using this medication for safety. Women who are pregnant or may become pregnant should not take this medication, and pre-menopausal women may need appropriate contraception while taking this medication due to increased risk of pregnancy. The risk of hypoglycemia may increase when used in combination with other diabetes medications, so patients should be aware of hypoglycemic symptoms, and dosage adjustments of combination medications may be necessary. Patients taking this medication should undergo regular monitoring of blood sugar, liver function tests, etc., and consult healthcare professionals if edema or weight gain occurs. Elderly patients should use this medication with caution, as the risk of side effects may be higher in older adults. In case of overdose, even if there are no special symptoms, it is important to inform healthcare professionals immediately to receive appropriate care. This medication has not been established as safe and effective for use in children; therefore, it is not recommended for use in this population. When storing the medication, it is important to keep it out of reach of children and to store it in its original container.

Serious side effects

Congestive heart failure, edema, severe allergic reactions (hives, severe swelling), difficulty breathing, cold sweat, pallor, liver abnormalities (jaundice), liver failure, severe skin reactions (severe rash with fever, blistering, skin peeling, mucosal pain in mouth/eyes), serious neurological symptoms (severe headache, thunderclap headache, seizures, confusion, vision abnormalities, paralysis), decreased urine output, elevated blood pressure, severe edema, worsening heart failure

Mild side effects

• Upper respiratory infection
• headache
• sinusitis
• myalgia
• pharyngitis
• abdominal distension
• weight gain
• hypoglycemia
• urinary tract infection
• low back pain

This medication should be stored in a tightly closed container that can protect it from light and air. Additionally, avoid overly humid areas, and store it in a cool place between 15 to 30 degrees Celsius, preferably around 25 degrees, to maintain the medication's efficacy and safety over time.

Appearance

White to off-white round tablets

Package unit

30 tablets/bottle, 100 tablets/bottle