Neuropezil Tablet 10 mg (Donepezil Hydrochloride Monohydrate)

Adult dose

○ Adults: Administer 5 mg of donepezil hydrochloride once daily before bedtime. If sleep disturbances such as unusual dreams, nightmares, or insomnia occur, morning administration of this medication may be considered. Since donepezil concentrations reach steady state 15 days after administration and the frequency of adverse reactions may be affected by the rate of dose increase, administer the 5 mg dose for 4~6 weeks. After evaluating the clinical response during this period, the dose may be increased to 10 mg. When increasing the dose to 10 mg daily, administer with caution for gastrointestinal adverse reactions. When this medication is discontinued, its effects gradually decrease, and no rebound effect occurs with abrupt discontinuation. ○ Female patients aged 85 years or older with low body weight: Careful monitoring is required because adverse reactions occur more frequently. Elderly women with low body weight should not exceed 5 mg daily.

Child dose

○ Pediatric patients: There is no experience with use in pediatric patients.

This drug uses Donepezil hydrochloride to alleviate symptoms of Alzheimer's dementia. Firstly, this drug should not be used in certain patients. It must not be administered to anyone who is allergic to this medication or its components, pregnant or potentially pregnant women, nursing mothers, and patients with genetic problems such as lactase deficiency or galactose intolerance. Caution is required when using this drug in patients with heart disease or cardiac conduction disorders, as it can slow the heart rate or cause arrhythmias. Additionally, patients with peptic ulcers or those taking non-steroidal anti-inflammatory drugs, as well as patients with a history of asthma or obstructive pulmonary disease, and patients with extrapyramidal disorders such as Parkinson's disease should use it cautiously. This drug can cause various side effects; in serious cases, symptoms such as fainting, heart problems, gastrointestinal bleeding, liver dysfunction, seizures, and movement disorders may occur. Mild side effects include nausea, vomiting, diarrhea, dizziness, insomnia, headaches, fatigue, and more. If side effects are severe or unusual symptoms occur, consultation with a doctor is necessary. This medication should be taken according to a doctor's instructions for improvement of dementia symptoms, and if there is no therapeutic effect or if side effects are severe, discontinuation may be necessary. Additionally, since this medication can affect driving or machinery operation, caution is needed. As this drug is metabolized in the liver, caution is necessary in patients with impaired liver function or liver disease. Furthermore, this drug may interact with other medications, so particularly when taken with drugs that affect the heart, antibiotics, antidepressants, or antipsychotics, consultation with a doctor or pharmacist is needed. Pregnant or nursing women are advised not to use this medication unless absolutely necessary, and should consult a specialist before deciding. Finally, the safety of this drug has not been confirmed in children, so it should not be used. In case of overdose, symptoms such as nausea, vomiting, bradycardia, and respiratory depression may occur, and immediate emergency treatment should be obtained, potentially using atropine as an antidote. This medication should be stored out of reach of children, and it is recommended not to transfer it to other containers.

• Syncope
• bradycardia
• heart block
• QT interval prolongation
• myocardial infarction
• heart failure
• peptic ulcer
• perforation of the duodenum
• gastrointestinal bleeding
• hepatitis

This medication should be stored in a tightly sealed container to prevent air intrusion, at room temperature between 1 degree and 30 degrees Celsius. Storing it this way helps maintain the drug's effectiveness for a longer period.

Appearance

Yellow round film-coated tablet

Package unit

30 tablets/bottle