Atriple Plus Injection (Pre-filled) (Sodium Hyaluronate)

Adult administration

Usually administered to adults once a week, one vial for three consecutive weeks into the knee joint or shoulder joint (shoulder joint cavity, subacromial bursa or biceps tendon sheath), though the frequency may be adjusted based on symptoms. This drug should be administered under strict sterile conditions.

This drug should not be administered to patients who have previously experienced allergic reactions to any component of this product. Caution should be exercised when administering to patients who have had allergic reactions to other medications or who have liver dysfunction or a history of liver disease. Liver function tests may show abnormal results in patients with liver dysfunction. Additionally, since this drug is administered directly into the joint, it should be used cautiously if there is any skin condition or infection at the site of injection. Severe allergic reactions such as shock symptoms may occur when using this drug, so patients must be closely monitored. If any unusual symptoms occur, administration should be immediately stopped and appropriate treatment should be provided. Common side effects may include swelling of the face or around the eyes, skin rash, hives, and itching, so if these symptoms occur, discontinuation and treatment should be sought. Transient pain, swelling, redness, warmth, and severe pressure sensation may occur at the injection site in the joint, and systemic symptoms such as nausea, vomiting, and fever may also appear. For patients with severe inflammatory degenerative joint disease, it is advisable to reduce inflammation before administering this product. After administration, measures to stabilize the joint area are necessary. If the drug leaks outside the joint, pain may occur, so it must be injected accurately into the joint. Sterile conditions must be strictly maintained during injection, and if symptoms do not improve, administration should only be done up to three times and then stopped. If there is significant accumulation of joint fluid, it may need to be drained as needed. This drug should not be administered intravenously or for ophthalmological use, and appropriate sized needles should be used. Caution is also required as precipitation may occur when mixed with certain disinfectants. Pregnant women or those who may become pregnant should only use this drug cautiously if absolutely necessary, and breastfeeding women should avoid breastfeeding while receiving this treatment. Safety has not been established in children, so it should only be used cautiously when necessary.

Serious side effects

Shock

Mild side effects

• Swelling (facial, eyelid, etc.)
• facial flushing
• rash
• itching
• transient pain after administration
• swelling
• redness
• warmth
• severe localized pressure sensation
• nausea

This drug should be stored in a sealed container to prevent exposure to air, and it is recommended to keep it at room temperature, between 1 to 30 degrees Celsius, to maintain its efficacy.

Appearance

A colorless, transparent, viscous liquid contained in a glass or plastic vial with rubber stoppers on both ends (part of a pre-filled syringe system)

Package unit

2 milliliters / pre-filled syringe (2ml x 3 vials) (for domestic use), 2 milliliters / pre-filled syringe (2ml x 1 vial) (for export), 2 milliliters / pre-filled syringe (2ml x 3 vials) (for export), 2 milliliters / pre-filled syringe (2ml x 10 vials) (for export)