Megerol Suspension (Megestrol Acetate)

Adult dose

(Tablets) 1. Breast cancer: Administer 160 mg of megestrol acetate orally per day in 4 divided doses (40 mg, 1 tablet per dose, 4 times daily). 2. Endometrial cancer: Administer 40～320 mg of this medication orally per day in divided doses. The effect of this medication should be assessed over an appropriate period, with treatment continued for at least 2 months. (Suspension) Shake well and take 800 mg (20 mL) of megestrol acetate per day. In clinical trials, clinical efficacy was observed with daily doses of 400～800 mg (10∼20 mL) of this medication.

This medication poses a serious risk to the fetus if administered to pregnant women; therefore, it should not be used by women who are pregnant or may become pregnant. Prolonged use of this medication may lead to the onset of diabetes or worsening of existing diabetes, and symptoms such as Cushing's syndrome due to hormonal imbalance may occur. Long-term use or abrupt discontinuation may lead to adrenal insufficiency, with symptoms like hypotension, nausea, vomiting, dizziness, and weakness; consultation with a healthcare professional is warranted in such cases. Patients who have had allergic reactions to this medication or its components should not use it, and those with a history of thrombosis or diabetes should use it cautiously. Side effects such as diarrhea, rash, abdominal bloating, hypertension, weakness, insomnia, nausea, anemia, fever, decreased libido, indigestion, headache, vomiting, pneumonia, frequent urination, amblyopia, constipation, dry mouth, liver enlargement, increased salivation, oral candidiasis, cardiomyopathy, palpitations, cough, pharyngitis, pulmonary dysfunction, leukopenia, proteinuria, incontinence, urinary tract infection, gynecomastia, sensory abnormalities, confusion, seizures, depression, and nervousness may occur during use; any unusual symptoms should be discussed with a physician. Though this medication is used for weight loss treatment, the cause of weight loss should first be clearly identified before use, and long-term use may increase the risk of respiratory infections. Pregnant or nursing women should avoid this medication as it may have fatal consequences for the fetus or infant, and nursing should be suspended during treatment. Safety for children has not been established, so it is advisable not to administer it to pediatric patients. There is no specific antidote in case of overdose; therefore, it is essential to adhere strictly to the prescribed dosage and store it out of reach of children and not transfer it to another container.

Diarrhea

This medication is sensitive to light and should be stored in a container that does not allow light to enter. It is also advisable to keep the medication at a cool temperature between 15 to 25 degrees Celsius.

Appearance

A white to pale yellow suspension with an orange flavor contained in a pouch that disperses easily when shaken.

Package unit

20 pouches/box [20 mL/pouch], 20 pouches/box [10 mL/pouch]