Rabert 10 mg (Rabeprazole Sodium)

Adult dose

Typically, 10 mg of rabeprazole sodium is administered orally once daily to adults. Depending on symptoms, 20 mg may be administered orally once daily. Normally, treatment for gastric ulcers is up to 8 weeks, and for duodenal ulcers, it's up to 6 weeks. For erosive or ulcerative gastroesophageal reflux disease, 10 mg or 20 mg should be given orally once daily for 4 to 8 weeks. If untreated, 10 mg or 20 mg may be further administered once daily for an additional 8 weeks.

This medication should not be used in patients who have hypersensitivity to specific components or benzimidazole derivatives, or have a history of such reactions. Additionally, patients allergic to amoxicillin or clarithromycin should not receive this medication when used in combination for the eradication of Helicobacter pylori. Patients taking certain drugs that may cause serious side effects when used in combination with this medication, such as terfenadine, cisapride, pimodivir, astemizole, or atazanavir, rilpivirine, should not use it. Pregnant or breastfeeding women should also avoid taking this medication due to insufficient safety data. Caution should be exercised in patients with impaired liver function, elderly patients, and those with a history of drug allergy. If symptoms such as rash, urticaria, or itching develop while taking this medication, it should be discontinued immediately and a doctor should be consulted. Regular blood tests may be required as changes in red or white blood cell counts can occur. Liver function tests should also be performed periodically due to the possibility of liver function abnormalities; if any abnormalities are found, use should be discontinued. A variety of side effects such as cardiovascular problems, gastrointestinal symptoms, headaches, dizziness, and respiratory difficulties may occur, so immediate consultation with healthcare professionals is necessary if these symptoms arise. This medication strongly suppresses gastric acid secretion, which may increase the risk of osteoporosis and fractures with long-term use. Additionally, prolonged use (over 3 months) may lead to hypomagnesemia, thus magnesium levels should be checked regularly. The risk of bacterial infections in the gastrointestinal tract may increase due to reduced gastric acid, so if symptoms such as diarrhea persist, medical attention should be sought. Caution is advised when driving or operating machinery, as drowsiness or dizziness may occur. This medication may interact with other drugs; therefore, it is essential to consult a physician or pharmacist about concomitant medications. Special care is needed when used in combination with warfarin, methotrexate, antibiotics, and antiviral drugs. Pregnant or breastfeeding women should not use this medication, and caution is necessary for elderly patients due to an increased risk of side effects from liver function decline. The safety in pediatric patients has not been established, so it is advisable to avoid using it in children. In cases of overdose, no specific antidote exists, and symptomatic treatment and supportive therapy are necessary; the tablets should not be chewed or crushed but swallowed whole. This medication should be kept out of reach of children, and it is advisable not to transfer it to other containers. Regular examinations and consultations with healthcare providers during prolonged use are important for safe administration.

Serious side effects

Urticaria, severe swelling, chest tightness, breathing difficulty, severe rash with fever, blistering, skin peeling, pain in oral/ocular mucosa, liver abnormalities (jaundice), sudden and severe headache, seizures, confusion, visual disturbances, paralysis, marked decrease in urine output, severe edema or urinary disturbances, fulminant hepatitis, toxic epidermal necrolysis (Lyell syndrome), Stevens-Johnson syndrome, cardiac arrhythmias (QT prolongation, ventricular)

Mild side effects

• Rash
• itching
• red blood cell reduction
• white blood cell reduction
• white blood cell increase
• eosinophilia
• neutrophilia
• lymphocyte reduction
• anemia
• petechiae

This medication should be stored in a tightly sealed container to protect it from air and moisture. It is important to maintain room temperature between 1 degree and 30 degrees Celsius.

Appearance

Pale yellow round enteric-coated tablet

Package unit

28 tablets (14 tablets/PTP packaging x 2), 28 tablets (14 tablets/Alu Alu packaging x 2)