Diamin XR Tablets (Metformin Hydrochloride)

Adult dose

The dosage should be determined based on individual drug efficacy and tolerability, and should not exceed the recommended maximum daily dose. The typical starting dose is 500 mg of metformin hydrochloride extended-release tablets taken once daily with the evening meal. Blood sugar levels should be measured one week later to adjust the dosage. The maximum dose is 2000 mg per day. When increasing the dosage, it should be increased by 500 mg weekly, with a maximum of 2000 mg taken once daily.

This medication can rarely cause a serious condition called lactic acidosis. Lactic acidosis is a state of excessive lactate accumulation in the body, leading to acidity, which may be life-threatening and requires caution. Severe hypoglycemia may occur when this medication is used with insulin or sulfonylureas, so blood sugar changes must be closely monitored when used in combination. This medication should not be used in patients with moderate to severe renal impairment or in patients with acute conditions that affect renal function, such as dehydration, severe infections, or heart failure. Use of this medication should be discontinued before and after examinations involving iodine-based radiologic contrast agents, and should only be resumed after renal function has returned to normal. Patients with allergic reactions to any component of this medication or those with type 1 diabetes or diabetic ketoacidosis should not receive this medication. In cases of severe infections, major trauma, or unstable patient conditions around the time of surgery, the use of this medication should be temporarily halted, and it can be resumed when the patient's condition stabilizes and renal function returns to normal. Patients with very poor nutritional status or liver dysfunction, or those consuming excessive alcohol should avoid this medication, and it should also be avoided if there are specific risks during pregnancy. Regular kidney function testing should be done during treatment with this medication, and elderly patients should be monitored more frequently due to a higher risk of renal impairment. Vitamin B12 deficiency may occur, so it is advisable to check this through regular blood tests. This medication may cause gastrointestinal symptoms (nausea, vomiting, diarrhea, etc.), which are mainly observed at the beginning of treatment, but usually resolve over time. If severe gastrointestinal symptoms or dehydration occur, the medication should be temporarily stopped. The risk of lactic acidosis increases when this medication is taken with alcohol, so it is important to avoid drinking. The effect of this medication may be increased or decreased when used with certain drugs; therefore, if you are taking other medications, you must consult with your doctor or pharmacist. This medication crosses the placenta during pregnancy, so it should be decided whether to use it after consulting a specialist when blood sugar control is needed during pregnancy. If breastfeeding, this medication is secreted into breast milk, so careful consideration should be given regarding whether to continue breastfeeding or to stop the medication treatment. Safety and efficacy have not been established for children and adolescents under 17 years of age, so it is not recommended. In case of overdose, hypoglycemia does not occur, but the drug may accumulate in the body, increasing the risk of lactic acidosis, so immediate notification to healthcare professionals is required, and blood dialysis may be helpful if necessary. This medication should be swallowed whole without chewing or crushing, and it is normal for the tablet coating to be expelled in the stool. During treatment with this medication, regular meals and exercise, as well as regular monitoring of blood sugar and kidney function, are important, and immediate consultation with healthcare professionals is necessary if symptoms change.

Serious side effects

lactic acidosis, severe allergic reactions (hives, severe swelling), hypoglycemia, liver abnormalities (jaundice), serious neurological symptoms, severe edema or urinary disturbances, respiratory problems

Mild side effects

• altered taste
• nausea
• vomiting
• diarrhea
• abdominal pain
• loss of appetite
• vitamin B12 deficiency
• erythema
• itching
• hives

This medication should be stored in a tightly closed container to protect it from air and moisture. It is advisable to maintain a storage temperature between 1 and 30 degrees Celsius (room temperature).

Appearance

White, biconvex, rectangular extended-release tablet

Package unit

30 tablets/bottle, 300 tablets/bottle