Lodien Tablet 2.5 mg (Esamlodipine Nicotinate)

Adult dose

The oral dose of esamlodipine is 2.5 mg once daily, and it may be increased to a maximum of 5 mg daily depending on the patient's response. Adjustments should be made appropriately based on symptoms.

Child dose

The oral dosing regimen for esamlodipine for effective blood pressure reduction is 1.25 mg to 2.5 mg once daily. Doses exceeding 2.5 mg per day have not been studied in pediatric patients.

This medication should not be used in certain patients. For instance, patients who are allergic to this medication or similar drugs, nursing mothers, patients in severe shock, those with severe aortic stenosis of the heart, patients with unstable angina, those who have recently suffered a myocardial infarction, and patients with severe liver dysfunction or hypotension should not take this medication. Moreover, patients with very poor kidney function, elderly individuals, those with acute heart failure, patients with rapidly elevated blood pressure, individuals with slightly impaired liver function, and women who are pregnant or may become pregnant should be especially cautious when using this medication. Taking this medication may cause flushing or a sensation of warmth, fatigue, or swelling. Symptoms such as rapid heartbeat, dizziness, headaches, discomfort in the stomach, or drowsiness may also occur. Rarely, symptoms such as dry mouth or excessive sweating, low blood pressure, chest pain, skin rashes, hair loss, or visual disturbances may appear, so any unusual symptoms should be reported to a doctor immediately. Abruptly stopping this medication may worsen symptoms, so the dose should be gradually reduced according to a doctor's instructions, and patients should be careful not to discontinue it arbitrarily. It is best to take this medication with a sufficient amount of water, and since low blood pressure may cause dizziness, patients should be cautious when driving or operating hazardous machinery. This medication can be taken together with other antihypertensives, certain antibiotics, analgesics, and antidiabetic drugs, but interactions with some medications may increase side effects, so it is essential to inform healthcare professionals about any medications being taken. In particular, it is advisable to avoid taking it with grapefruit juice as it may enhance the drug's effects. Women who are pregnant or breastfeeding should consult a doctor before taking this medication, and if breastfeeding, it is recommended to stop nursing. It is approved for use in children aged 6 and older; safety and efficacy have not been established for children under 6 years of age. For elderly patients, the concentration of the drug may increase, so starting with a lower dose and carefully monitoring the condition is necessary. If this medication is overdosed, symptoms such as severe hypotension, rapid heartbeat, or coma may occur, so appropriate treatment should be sought immediately at a medical institution. This medication should be stored out of reach of children, and transferring it to another container may alter its quality, so it is advisable to keep it in its original packaging.

Serious side effects

Urticaria, angioedema, toxic epidermal necrolysis, biliary tract abnormalities (hepatitis, jaundice), severe swelling, paralysis.

Mild side effects

• Flushing with a sensation of warmth
• fatigue
• swelling
• palpitations
• dizziness
• headaches
• migraines
• weakness
• abdominal pain
• nausea

This medication may be sensitive to air or moisture, so it must be stored in a tightly closed container. Additionally, it is best to keep the medication at room temperature between 1 to 30 degrees Celsius, avoiding too hot or too cold places. Storing it this way helps maintain the drug's efficacy and ensures safe use.

Appearance

White pentagonal tablets

Package unit

300 tablets/bottle, 30 tablets (10 tablets/PTP packaging x 3)