SK Coscaplus Tablet

Adult dose

The recommended dosage is Losartan Potassium 50 mg/Hydrochlorothiazide 12.5 mg, 1 tablet once daily. A dosage exceeding Losartan Potassium 100 mg/Hydrochlorothiazide 25 mg per day is not preferred. For cases where blood pressure is not controlled, initiate treatment with Losartan Potassium 50 mg/Hydrochlorothiazide 12.5 mg, 1 tablet once daily, and if blood pressure remains uncontrolled after 3 weeks, the maximum dose may be increased accordingly.

Child dose

Due to lack of experience in pediatric use, the Losartan-Hydrochlorothiazide combination should not be administered to children and adolescents.

This drug can cause serious harm to the fetus especially in the second and third trimesters of pregnancy; therefore, it should be discontinued immediately upon confirmation of pregnancy. This drug should not be used in patients with certain conditions, such as those with anuria, severe electrolyte imbalances, severe liver or kidney dysfunction, and in women who are pregnant or may become pregnant. Patients with excessively low blood pressure or renal function issues, those with a history of hyperuricemia or gout, and the elderly should use this drug with caution, as the risk of skin cancer may increase and exposure to sunlight should be limited while periodically checking skin conditions. This drug primarily lowers blood pressure, and symptoms like dizziness, cough, swelling, abdominal pain, or rash may occur. If abnormal symptoms appear, medical consultation is advised. This drug can affect serum potassium levels, so it is best not to take it with potassium supplements or medications containing potassium. It may interact with other medications like antihypertensives or diuretics, so inform your healthcare provider about any medications you are taking. Regular blood tests are important to monitor electrolyte levels and kidney function while taking this medication, and you should inform your doctor immediately if symptoms of fluid or electrolyte imbalance occur. This drug has not been tested for use in children or adolescents, so it should not be administered to them. Dizziness or drowsiness may occur when driving or operating machinery, so be cautious, especially at the beginning of treatment or when changing the dosage. This medication should be kept out of reach of children and stored in its original container to prevent misuse or degradation of quality.

Serious side effects

• Urticaria, severe swelling (edema), angioedema (swelling of the lips and eyelids along with facial rash, laryngeal/pharyngeal swelling), tightness in the chest
• Difficulty breathing, shortness of breath, acute respiratory distress syndrome (ARDS), pneumonia, and pulmonary edema
• Cold sweat, pallor
• Severe rash with high fever, blisters, skin peeling, pain in mucous membranes of the mouth/eyes
• Yellowing of skin or eyes (jaundice), intrahepatic cholestatic jaundice

Mild side effects

• Systemic: Abdominal pain, weakness/fatigue, diarrhea, nausea, headache, malaise, fever, syncope, orthostatic hypotension, hypotension, increased serum creatinine levels
• Cardiovascular: Palpitations, angina, arrhythmias (atrial fibrillation, bradycardia, tachycardia, ventricular tachycardia, ventricular fibrillation), myocardial infarction, secondary AV block
• Gastrointestinal: Loss of appetite, constipation, dental pain, dry mouth, dyspepsia, flatulence, gastritis, vomiting
• Musculoskeletal: Low back pain, arm pain, joint pain, arthritis, fibromyalgia

This medication should be stored in a container that blocks light exposure and kept tightly sealed to prevent air infiltration. It is best to maintain a storage temperature between 1 to 30 degrees Celsius.

Appearance

Yellow oval film-coated tablet

Package unit

30 tablets/bottle, 300 tablets/bottle