Rosaplus-EF Tablet

Adult dose

The usual dosage is 50 mg of losartan potassium/12.5 mg of hydrochlorothiazide, taken once a day with one tablet. A dose exceeding 100 mg of losartan potassium/25 mg of hydrochlorothiazide per day is not advisable. If blood pressure is not controlled, therapy should start with 50 mg of losartan potassium/12.5 mg of hydrochlorothiazide once daily, and if blood pressure remains uncontrolled after 3 weeks, the dose can be increased to a maximum of 100 mg of losartan potassium/25 mg of hydrochlorothiazide once daily.

Child dose

Experience with the use of this medication in children and adolescents (under 18 years old) is lacking, therefore the Losartan-hydrochlorothiazide combination should not be administered.

This medication can cause serious harm to the fetus when taken during pregnancy, especially in the second and third trimesters, so it should be discontinued immediately if pregnancy is confirmed. Patients with allergies to this drug or its components, certain kidney diseases, liver diseases, or electrolyte imbalances should not take this medication. Patients with specific diseases or conditions such as hypotension, kidney impairment, liver impairment, hyperuricemia, diabetes, or the elderly should exercise special caution when taking this medication. During treatment, blood pressure, kidney function, and electrolyte levels should be monitored regularly to check for abnormal signs, with particular attention to hypokalemia or hyperkalemia. This drug has a blood pressure-lowering effect, so dizziness or drowsiness may occur when starting or adjusting the dose, which requires caution when driving or operating machinery. There may be interactions with other drugs, so it is essential to consult a doctor or pharmacist, especially if taking potassium supplements, diuretics, antihypertensives, non-steroidal anti-inflammatory drugs (NSAIDs), or lithium. The hydrochlorothiazide component can react sensitively to sunlight, so prolonged exposure to sunlight should be avoided; if there are skin reactions, notify a doctor immediately. Pregnant women or women who may become pregnant should not take this medication, and breastfeeding women should either discontinue breastfeeding or consult a doctor before taking it. Safety for children and adolescents has not been established, so this medication should not be administered to minors. Overdose may result in symptoms such as hypotension, changes in heart rate, and electrolyte imbalances, so if abnormal symptoms occur, medical attention should be sought immediately. This medication should be stored in its original container, kept out of the reach of children, and not shared or transferred to other containers.

Serious side effects

Urticaria, angioedema (including swelling of lips and eyelids and facial rash), skin exfoliation and hemolysis, chest pain, facial swelling, syncope, angina, arrhythmia (atrial fibrillation, sinus bradycardia, tachycardia, ventricular tachycardia, ventricular fibrillation), cerebral vascular accident, hypotension, myocardial infarction, secondary atrioventricular block, blood coagulation disorders (thrombocytopenia), acute respiratory distress syndrome (ARDS), dyspnea, vasculitis (Henoch–Schönlein purpura),

Mild side effects

Abdominal pain, edema/swelling, palpitations, back pain, dizziness, cough, sinusitis, upper respiratory infection, weakness/fatigue, diarrhea, nausea, headache, bronchitis, pharyngitis, chest pain, facial swelling, fever, orthostatic hypotension, syncope, angina, arrhythmia (atrial fibrillation, sinus bradycardia, tachycardia, ventricular tachycardia, ventricular fibrillation), hypotension, myocardial infarction, secondary atrioventricular block, loss of appetite, constipation, toothache, dry mouth, dyspepsia, flatulence, gastritis, vomiting, lethargy,

This drug is sensitive to light and should be stored in a container that blocks light. It is also recommended to store the medication at room temperature, between 1 and 30 degrees Celsius.

Appearance

Pale yellow oval film-coated tablet

Package unit

30 tablets/bottle, 300 tablets/bottle