Diabic Extended Release Tablet (Metformin Hydrochloride)

Adult dose

The dosage should be determined based on individual drug response and tolerance and should not exceed the recommended maximum daily dose. The usual initial dose is 500 mg of Metformin Hydrochloride extended-release tablet taken once daily with the evening meal. Blood sugar levels should be measured after one week to adjust the dosage. Gastrointestinal adverse reactions may improve with gradual dose increases. The maximum dose is 2000 mg per day.

This medication can rarely cause a serious condition called lactic acidosis. Lactic acidosis occurs when there is an excessive accumulation of lactic acid in the body and can be life-threatening in severe cases. Caution is required when using this medication with other diabetes treatments, as hypoglycemia may occur. It should not be administered to patients with moderate to severe renal impairment, dehydration, serious infections, or acute conditions that may affect renal function, such as acute myocardial infarction. Patients with acute and unstable heart failure or those receiving iodinated contrast agents used in certain radiological examinations should also avoid this medication. In these cases, the medication should be discontinued before and for a certain period after the tests. Do not use this medication if you have an allergy to any of its components, type 1 diabetes, diabetic ketoacidosis, severe infections, or severe liver dysfunction. Patients scheduled for surgery should stop the medication 48 hours prior and resume only after renal function has been confirmed as normal. This medication should be used cautiously in cases of irregular eating, vigorous exercise, or drug interactions, as the risk of hypoglycemia and lactic acidosis may increase. During treatment, monitoring for potential side effects such as vitamin B12 deficiency, gastrointestinal disturbances (nausea, vomiting, diarrhea), and skin rashes is important. Regular assessment of renal function is necessary to reduce the risk of drug accumulation and lactic acidosis, especially in elderly patients or those with reduced renal function, who may require dose adjustment. Alcohol consumption and acute or chronic excessive alcohol intake should be avoided due to increased risk of lactic acidosis. During pregnancy, fetal and maternal conditions should be closely monitored, and careful consideration should be given to the use of this medication during breastfeeding. It is not recommended for children as safety and efficacy have not been established. In the event of overdose, the drug can be removed through hemodialysis, so immediate consultation with medical personnel is advised if overdose is suspected. Lastly, this medication should be swallowed whole without crushing or chewing the tablets, and it is normal for the shell of the tablet to be excreted in the stool.

Serious side effects

Lactic acidosis (acute renal failure, cardiopulmonary disease, sepsis-related), hypoglycemia, severe allergic reactions (hives, etc.), serious skin adverse reactions (erythema, hives, rash), severe edema (generalized severe swelling), severe allergic reactions, respiratory issues (shortness of breath, etc.), liver abnormalities (jaundice), severe neurological symptoms (headache, confusion, etc.)

Mild side effects

• Vitamin B12 deficiency
• taste impairment
• nausea
• vomiting
• diarrhea
• abdominal pain
• loss of appetite
• erythema
• itching
• hives

Store this medication in a tightly closed container to protect it from air and moisture. It is best to keep the storage temperature between 1 to 30 degrees Celsius at room temperature.

Appearance

White oblong tablets

Package unit

30 tablets, 300 tablets (bottle)