International Lozartan Plus F Tablet

Adult dose

The usual dose for adults is 50 mg of losartan potassium/12.5 mg of hydrochlorothiazide taken once daily as one tablet. Dosages exceeding 100 mg of losartan potassium/25 mg of hydrochlorothiazide in one day are not recommended. Generally, the maximum antihypertensive effect is observed approximately 3 weeks after starting the treatment. This medication may be administered together with other antihypertensive agents and can be taken regardless of meals. The following and

Child dose

There is no experience in children and adolescents (under 18 years); therefore, the losartan-hydrochlorothiazide combination should not be administered.

This medication can cause serious harm or even death to the fetus when taken during pregnancy, especially in the second and third trimesters, so it should be discontinued immediately upon confirmation of pregnancy. This medication should not be administered to patients with certain diseases or conditions, such as anuria, severe liver impairment, severe kidney dysfunction, pregnant women, and specific genetic lactase deficiency patients. Precautions are necessary when using this medication in patients with low blood pressure, kidney disease, liver disease, electrolyte abnormalities, diabetes, gout, and elderly patients. While this medication lowers blood pressure, it may affect potassium levels, so caution is necessary when used with potassium supplements or medications containing potassium. Dizziness and drowsiness may occur during treatment, so care should be taken when driving or operating machinery. It is important to regularly check kidney function and electrolyte status through blood tests while taking this medication. The hydrochlorothiazide component may cause sensitivity to sunlight, so exposure to ultraviolet light should be reduced, and if there are skin abnormalities, the patient should consult a doctor immediately. There is no experience with this medication in children or adolescents, and it is advisable not to administer it to them. In the case of overdose, symptoms such as hypotension and tachycardia may occur, requiring immediate medical attention. Patients who plan to become pregnant or are pregnant while taking this medication should consult a doctor, and it is also recommended to discontinue use while breastfeeding or to stop breastfeeding. This medication may interact with other drugs, so it is imperative to inform healthcare providers of any concurrent medications, particularly potassium-sparing diuretics, lithium, nonsteroidal anti-inflammatory drugs, etc. Keep this medication out of reach of children and store it in its original container to prevent quality deterioration or misuse.

Serious side effects

• Hives, severe swelling (edema), angioedema (swelling of lips and eyelids and facial rash)
• Chest discomfort
• Difficulty breathing, shortness of breath, acute respiratory distress syndrome (ARDS)
• Cold sweat
• Pallor
• Severe rash with high fever, blisters, skin peeling, pain in mouth/eyes mucous membranes
• Jaundice (skin or eyes turning yellow), intrahepatic cholestatic jaundice
• Severe lethargy
• Sudden and very severe headache, migraine, seizures, confusion

Mild side effects

• General: Abdominal pain, weakness/fatigue, diarrhea, nausea, headache, malaise, fever, syncope, hypotension
• Cardiovascular: Palpitations, angina, arrhythmias (atrial fibrillation, sinus bradycardia, tachycardia, ventricular tachycardia, ventricular fibrillation), cerebrovascular accidents, myocardial infarction, secondary atrioventricular block
• Gastrointestinal: Anorexia, constipation, toothache, dry mouth, dyspepsia, flatulence, gastritis, vomiting, dry mouth, gastrointestinal irritation, pancreatitis
• Musculoskeletal: Back pain, arm pain, joint pain, arthritis, fibromyalgia

This medication is sensitive to light; therefore, it must be stored in a special container that prevents light exposure. Additionally, it should be stored at room temperature, ideally between 1 degree and 30 degrees Celsius.

Appearance

Pale yellow oval film-coated tablet

Package unit

30 tablets/bottle, 300 tablets/bottle