Rozet Plus Tablet

Adult dose

The standard dosage for adults is 1 tablet of Losartan Potassium 50 mg/Hydrochlorothiazide 12.5 mg once daily. A dosage exceeding 100 mg of Losartan Potassium/25 mg of Hydrochlorothiazide per day is not desirable. If blood pressure is not controlled, the dosage may be increased to a maximum of 1 tablet of Losartan Potassium 100 mg/Hydrochlorothiazide 25 mg once daily after 3 weeks of treatment. For patients with renal impairment whose creatinine clearance is 30 mL/min or more, the standard dosage should be administered.

Child dose

There is no experience with use in children and adolescents, so the combination of losartan and hydrochlorothiazide is not administered to children and adolescents.

This medication can severely harm a fetus if taken during pregnancy, especially in the second and third trimesters, so it should be discontinued immediately upon confirmation of pregnancy. This drug should not be administered to patients with certain allergies, severe renal impairment, severe hepatic impairment, or to women who are pregnant or may become pregnant. Caution should be exercised when using this medication in patients with very low blood pressure, renal vascular issues, weak liver function, hyperuricemia, or gout. Symptoms such as dizziness, hypotension, and electrolyte imbalance may occur during treatment; therefore, attention should be paid to these symptoms. Due to the hydrochlorothiazide component, electrolyte imbalances can occur, so regular blood tests are recommended, and immediate consultation with a doctor is necessary in cases of severe vomiting or diarrhea. This drug may increase the risk of skin cancer due to heightened sensitivity to sunlight, so sun exposure should be avoided, and any skin abnormalities should be reported to a doctor immediately. The combination of this drug with other antihypertensive drugs or potassium supplements may dangerously alter serum potassium levels, thus medical guidance must be followed. There may be dizziness or drowsiness when driving or operating machinery, so caution is advised, particularly at the beginning of treatment or when there is a change in dosage. If any abnormal symptoms or allergic reactions occur during treatment, use should be discontinued immediately and medical advice sought. There is no confirmed safety for use in children and adolescents, so use is not recommended.

Serious side effects

Hives, severe swelling, angioedema, angioedema (airway obstruction), peeling skin on palms, hemolysis, chest pain, facial swelling, fever, orthostatic hypotension, fainting, angina, arrhythmia (atrial fibrillation, sinus bradycardia, tachycardia, ventricular tachycardia, ventricular fibrillation), cerebrovascular accident, hypotension, myocardial infarction, secondary atrioventricular block, thrombocytopenia, purpura, necrotizing vasculitis, pneumonia, pulmonary edema, acute respiratory distress syndrome, jaundice, renal failure, interstitial nephritis

Mild side effects

• Abdominal pain
• swelling
• palpitations
• back pain
• dizziness
• cough
• sinusitis
• upper respiratory tract infection
• weakness/fatigue
• diarrhea

This medication is sensitive to light and should be stored in a special container that does not allow light to enter. Additionally, to maintain the efficacy of the medication, it should be stored at a temperature between 1 to 30 degrees Celsius.

Appearance

Yellow oval film-coated tablet

Package unit

30 tablets/bottle, 300 tablets/bottle