International Amlodipine Tablets 5 mg (Amlodipine Besylate)

Adult dose

Adults should take 5 mg of amlodipine orally once a day. The dose may be increased to a maximum of 10 mg per day depending on the patient's response. Adjust as appropriate based on age and symptoms.

This medication should not be used in certain patients. For example, it is contraindicated in individuals with allergies to this drug or similar classes of medications, nursing mothers, patients with severe liver dysfunction, severe aortic stenosis, and patients in shock. It should be used with caution in patients with severe hypotension, those requiring dialysis for renal failure, the elderly, and pregnant or potentially pregnant women. While taking this medication, various side effects may occur. The most common side effects include facial flushing, fatigue, edema, palpitations, dizziness, headache, drowsiness, abdominal pain, and nausea. Rarely, symptoms such as excessive drop in blood pressure, vasculitis, sensory abnormalities, erectile dysfunction, gynecomastia, dyspepsia, weight changes, skin rash, and liver function abnormalities may occur, and if any unusual symptoms appear, patients should immediately consult their doctor. Patients with heart or liver problems should be especially cautious when using this medication, and blood pressure changes may occur if the medication is abruptly discontinued, so follow the physician's instructions. This medication may interact with other drugs, so it is essential to consult with a doctor or pharmacist, especially when taking it with grapefruit juice or certain antibiotics, antihypertensives, or immunosuppressants. For women who are pregnant or nursing, it is advisable to avoid use unless specifically required, and nursing mothers are recommended to stop breastfeeding while on this medication. In children, use is only recommended for those aged 6 years and older, as safety and efficacy have not been established for younger ages. For the elderly, a general dosage is recommended, and tolerance appears to be similar to that of younger individuals. In the case of overdose, there may be excessive hypotension and increased heart rate, so immediate medical attention is required, and be cautious as this medication is not removed by hemodialysis. There is no evidence that this medication increases the risk of cancer or genetic abnormalities, even with long-term use.

Serious side effects

Hives, severe swelling (edema), exfoliative dermatitis, pain of oral/ocular mucosa, difficulty breathing, chest tightness, cold sweat, pallor, severe rash with high fever, asthma attacks, respiratory distress accompanied by cough+fever, yellowing of the skin or eyes (jaundice), profound lethargy, sudden and severe headache, lightning headache, seizures, confusion of consciousness, visual disturbances, paralysis, markedly reduced urine output, severe general malaise,

Mild side effects

• Flushing
• fatigue
• edema
• palpitations
• dizziness
• headache
• drowsiness
• abdominal pain
• nausea
• weakness

This medication should be stored in a tightly closed container, away from direct sunlight, and at room temperature. Doing so will help maintain the drug's effectiveness for an extended period.

Appearance

White octagonal tablets

Package unit

300 tablets/bottle, 30 tablets (10 tablets/PTP × 3)