Clopact Tablet (Clopidogrel Sulfate)

Adult dose

1. For patients with ischemic stroke, myocardial infarction, or peripheral arterial disease, take Clopidogrel at a dose of 75 mg once daily orally. 2. For patients with acute coronary syndrome, initiate with a loading dose of 300 mg once daily orally on the first day, followed by a maintenance dose of 75 mg once daily orally. Aspirin 75 to 325 mg should be co-administered once daily at this time. 3. For patients with atrial fibrillation, take 75 mg once daily orally.

This medication is used to prevent blood clots by helping the blood flow more easily, thereby helping to prevent heart attacks and strokes. Individuals with a genetic impairment of a specific enzyme (CYP2C19) may exhibit reduced efficacy of this medication, and in such cases, alternative treatment options should be considered. It is advisable not to co-administer this drug with certain medications (CYP2C19 inducers), as the concentration of the drug in the body may increase and the risk of bleeding may be elevated. Due to an increased risk of bleeding, individuals with a history of bleeding, severe liver impairment, those who are breastfeeding, or have certain genetic disorders should avoid using this medication. Patients with a high risk of bleeding, those about to undergo surgery, or patients on other bleeding risk medications should use this medication cautiously, and the medication should be discontinued for a certain period before surgery. This medication may cause side effects such as bleeding, reduced blood cell count, gastrointestinal symptoms (abdominal pain, diarrhea, etc.), and skin rashes; immediate consultation with a physician is warranted if any abnormal symptoms occur. If bleeding symptoms appear, inform medical personnel immediately, and it may be necessary to monitor the condition through blood tests. During pregnancy, the risk to the fetus is minimal, but there is a risk of bleeding at the time of delivery; thus, discontinuation of the medication prior to childbirth is recommended. In the case of breastfeeding, consider stopping the breastfeeding or discontinuing the medication, as it may be excreted in breast milk. Use in children is not recommended as the safety and efficacy have not been established. Elderly patients may have reduced physiological functions, increasing the risk of side effects like bleeding, thus dose adjustment and careful monitoring are necessary. Due to significant drug interactions, always inform healthcare providers about the use of this medication before starting new drugs or prior to surgery. Overdose may increase the risk of bleeding, and as there is no specific antidote, treatment such as platelet transfusions may be necessary in case of severe bleeding. Store this medication out of reach of children, and do not transfer it to other containers.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with fever, blisters, peeling skin, pain in mucous membranes (mouth/eyes), difficulty breathing or shortness of breath, asthma attack, respiratory distress with cough and fever, skin or eye yellowing (jaundice), extreme lethargy, sudden and severe headache, thunderclap headache, seizure, alteration of consciousness, visual disturbances, paralysis, urination

Mild side effects

• Headache
• dizziness
• abdominal pain
• dyspepsia
• diarrhea
• nausea
• fatigue
• rash
• pruritus
• purpura

The medication should be stored in a tightly sealed container to protect it from exposure to air and moisture. It is crucial to maintain a storage temperature between 1°C and 30°C at room temperature. Proper storage will help maintain the medication's effectiveness and ensure safe usage.

Appearance

Pink round film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle