Jungwoo Hemobi No. 2 Solution (Sodium Bicarbonate)

Adult dosage

Depending on the patient's condition and the type of artificial kidney used, appropriate acidic solution for hemodialysis should be selected and used after diluting with this solution and purified water.

This medication is a dialysate used in hemodialysis to help improve metabolic acidosis in patients with chronic kidney failure. Caution is required when using this medication in patients with severe liver impairment or severe diabetes that may impact acetate metabolism. If acetate is not properly metabolized, it may suppress heart function and lead to peripheral vasodilation, which can cause hypotension. Patients taking digitalis preparations should be administered with caution as low serum potassium levels can increase the risk of digitalis toxicity. Patients with high serum calcium and phosphorus levels before dialysis may need to be monitored for metastatic calcification. Be cautious in patients who have inadequate caloric intake, dietary restrictions due to diabetes, or are on hypoglycemic agents as they may experience a risk of hypoglycemia. Hypoglycemic symptoms may occur during or after dialysis, and in such cases, appropriate measures such as glucose injections or sugar intake should be taken. Since serum calcium levels may increase, it is advisable to switch to a low calcium dialysate if hypercalcemia is suspected. Bone-related complications such as osteoporosis, osteomalacia, and fibrous osteitis may occur, necessitating appropriate treatment such as administering active vitamin D3 preparations. If metastatic calcification occurs, phosphate binders should be used to maintain serum phosphorus levels within the normal range. Dialysis disequilibrium syndrome may occur presenting symptoms such as headache, nausea, vomiting, seizures, and altered consciousness, requiring actions to reduce dialysis efficiency. An abrupt decrease in circulating blood volume can lead to symptoms of hypotension or shock, in which case dialysis should be discontinued or the efficiency reduced, and fluid or antihypotensive agents administered. Dialysis dilution water must be safe water that has undergone strict purification processes, and care should also be taken with regards to dialysis membrane integrity and post-operative bleeding tendencies. When compounding, do not mix the electrolyte solutions intended for hemodialysis directly with sodium bicarbonate solutions, and ensure to prepare with the specified diluent accurately. If the dilution concentration is too high or too low, side effects such as headache, palpitations, blood pressure changes, or altered consciousness may occur, so caution is necessary. Before use, the electrolyte concentration, osmotic pressure, and pH of the dialysis solution must be verified to ensure they are appropriate. Remaining sodium bicarbonate solution should not be used, and this medication should not be used for injection or peritoneal perfusion. The dialysate should be used immediately after preparation, and care should be taken as insoluble substances can form if stored at 38°C for more than 2 hours. Pregnant women or women who may become pregnant should only use this medication when the therapeutic benefits outweigh the risks, as its safety has not been established. Safety in pediatric patients has not been established, so special caution is required. For elderly patients, the characteristics of this medication should be carefully considered, and regular monitoring and administration of vitamin D3 preparations are recommended to prevent bone complications if used for extended periods. This medication may cause side effects such as blood sugar fluctuations, weight gain, and increased blood pressure when used with acidic solutions containing glucose, thus regular monitoring of blood sugar, weight, and blood pressure should be practiced.

Mild side effects

• Hypoglycemia
• hypercalcemia
• osteoporosis
• osteomalacia
• fibrous osteitis
• metastatic calcification
• headache
• nausea
• vomiting
• seizures

This medication should be stored in a sealed container to prevent air and moisture ingress. Additionally, it is recommended to keep it away from direct sunlight and store it in a cool room temperature.

Appearance

A colorless, transparent liquid contained in a white translucent plastic bottle.

Package unit

10 liters