Amendin Tablet (Memantine Hydrochloride)

Adult dose

Treatment must be initiated by a physician with experience in diagnosing and treating Alzheimer's dementia, and only when a caregiver can periodically check the patient's medication adherence. This medication can be taken regardless of food intake. Dose escalation process: First week (Day 1-7): Administer 5mg once daily for 7 days. Second week (Day 8-14): Administer 10mg once daily (5mg twice daily) for 7 days.

This medication should not be used by patients who are allergic to its components. It should also not be administered to patients with very poor liver function or severely impaired kidney function. Patients with epilepsy or those who have experienced seizures in the past, as well as those prone to seizures, should use this medication with caution. Additionally, co-administration with NMDA antagonists such as amantadine, ketamine, and dextromethorphan may exacerbate side effects, so they should not be combined. Caution is also necessary if factors that change urine acidity (pH) or excessive intake of alkaline beverages are present. There is no established safety in patients with recent myocardial infarction, heart failure, or uncontrolled hypertension, so administration should be done carefully. Side effects such as dizziness, headache, constipation, drowsiness, and hypertension may occur, and if symptoms worsen, patients should consult their physicians. Rare reports of mental confusion, hallucinations, and psychotic symptoms have been noted, so if these symptoms occur, immediate notification to healthcare professionals is required. This medication can interact with other drugs, particularly NMDA antagonists, antipsychotics, muscle relaxants, and anticoagulants, so caution is necessary when taken together. Women who are pregnant or may become pregnant should consult a physician before using this medication, and it is advisable to stop breastfeeding if nursing. It is preferable not to use this medication in children or adolescents under 18 years of age, as safety and efficacy have not been established. In cases of overdose, central nervous system symptoms and gastrointestinal symptoms may occur, and immediate hospital visit for appropriate treatment is necessary. Caution should be exercised when driving or operating machinery while taking this medication, especially for Alzheimer's patients, who should avoid these activities for safety. This medication should be kept out of reach of children and should not be transferred to another container.

Serious side effects

Seizures, psychotic reactions, hallucinations, vascular disorders including venous thrombosis/thromboembolism, dyspnea, heart failure

Mild side effects

• Dizziness
• headache
• constipation
• drowsiness
• hypertension
• fungal infection
• drug hypersensitivity
• confusion
• hallucination
• psychotic reactions

This medication should be stored in a sealed container to protect it from air and moisture, and it is safest to keep it at room temperature between 1°C and 30°C. This will maintain the medication's effectiveness and prevent degradation.

Appearance

White oval film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle