Silvercept Tablet 10 mg (Donepezil Hydrochloride Hydrate)

Adult dose

As donepezil hydrochloride, take 5 mg once daily before bedtime. Administer 5 mg for 4-6 weeks, then based on clinical response assessment, the dose can be increased to 10 mg. If disturbances in sleep such as strange dreams, nightmares, or insomnia occur, morning administration may be considered. Underweight women patients over 85 years old should not exceed 5 mg daily and require careful monitoring.

Child dose

No experience in pediatric usage.

This medication contains donepezil hydrochloride as the active ingredient and is used for the treatment of Alzheimer's dementia symptoms. First, this medication should not be administered to certain patients. For example, patients who are allergic to this medication or its components, pregnant women or women who may become pregnant, and nursing mothers should not use this medication. Additionally, patients with heart diseases or conduction disorders, a history of peptic ulcers or those currently taking non-steroidal anti-inflammatory drugs, patients with asthma or obstructive pulmonary disease histories, and patients with extrapyramidal disorders such as Parkinson's disease should exercise special caution when using this medication. This medication may stimulate the vagus nerve, potentially causing a decrease in heart rate, increasing gastrointestinal motility leading to exacerbation of peptic ulcer symptoms, and may provoke bronchoconstriction worsening respiratory symptoms. During treatment, serious side effects such as syncope, bradycardia, heart block, gastrointestinal bleeding, liver dysfunction, cerebrovascular disorders, symptoms of extrapyramidal disorder, neuroleptic malignant syndrome, rhabdomyolysis, respiratory distress, acute pancreatitis, acute renal failure, and sudden death may occur, so if symptoms appear, immediate consultation with healthcare professionals is essential. Also, various side effects such as nausea, vomiting, diarrhea, loss of appetite, dizziness, insomnia, hallucinations, anxiety, drowsiness, palpitations, skin rash, myalgia, etc., have been reported, so caution is required when these symptoms occur. This medication may have side effects related to heart rate, thus patients with heart diseases may require monitoring through electrocardiogram testing. Furthermore, this medication increases gastric acid secretion and promotes gastrointestinal motility, potentially causing symptoms to worsen in patients with peptic ulcers, so caution is advised. It can affect the ability to drive or operate machinery; therefore, initial doses or dosage changes may lead to symptoms like fatigue, dizziness, and muscle cramps requiring attention. This medication may interact with various drugs, so particularly when used together with medications affecting CYP3A4 and CYP2D6 enzymes, drugs affecting cardiac conduction, cholinergic drugs, or anticholinergic drugs, consult healthcare professionals. Pregnant or nursing women should avoid using this medication, and in cases where it is deemed necessary, consultation with a specialist should be undertaken before making a decision. Safety in children has not been established, and this medication should not be used in pediatric patients. Overdosage may present symptoms such as nausea, vomiting, sweating, bradycardia, hypotension, respiratory depression, and seizures; therefore, appropriate medical treatment should be sought immediately. Lastly, this medication should be stored out of the reach of children and should not be transferred to other containers.

Serious side effects

• Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe allergic reactions
• Severe rash with fever, blisters, skin peeling, pain in mouth/eyes membranes, severe skin adverse reactions
• Shortness of breath or difficulty breathing, asthma attacks, respiratory abnormalities accompanied by cough and fever
• Yellowing of skin or eyes (jaundice), extreme lethargy, liver abnormalities (jaundice)
• Sudden and severe headache

Mild side effects

• Dizziness
• diarrhea
• nausea
• vomiting
• headache
• fatigue
• fever
• body aches
• insomnia
• hallucinations

This medication should be stored in a sealed container to prevent air from entering, and it is recommended to store it at room temperature between 1 and 30 degrees Celsius. This will help maintain the medication's effectiveness for a longer period.

Appearance

Yellow round film-coated tablet

Package unit

30 tablets/bottle, 200 tablets/bottle