Custodial Solution

Adult administration

1) Heart For adults, this medication should be cooled to 5 ～ 8 ℃ and administered via hydrostatic pressure (the initial height of the bag should be placed 140 cm above the heart - 100 mmHg) or given in a consistent amount by a pump for coronary artery infusion. After cardiac arrest (within the first minute after the start of infusion), the height of the bag should be lowered to 50 ～ 70 cm above the heart to achieve a pressure of 40 ～ 50 mmHg.

This medication should not be used for direct injection into veins or arteries. It is to be used only when the heart has stopped or for selective perfusion of the kidneys and liver, and for the purpose of cooling organ surfaces during the transport of organs from donors to recipients or preserving vascular grafts. This medication should never be used for systemic circulation, as it is not suitable for that purpose. There have been no reported adverse reactions in human or animal studies, clinical trials, or academic literature related to this medication, and no adverse reactions associated with it were found in a domestic survey conducted on 716 people over six years. However, since the components of this medication may alter electrolyte concentrations in the bloodstream when it enters systemic circulation, it is essential to carefully monitor calcium, sodium, potassium, and magnesium levels and adjust as necessary. It should be stored out of reach of children and is not suitable for replenishing systemic circulation or as an amino acid and electrolyte substitute. No interactions have been reported with some medications used during surgery or hospitalization, but caution should be exercised. Since there is no experience using this medication in pregnant or breastfeeding women, the risks and benefits should be carefully evaluated, and in emergencies, efforts should be made to ensure that it is completely eliminated from the heart. This medication should not be mixed with other drugs, and especially when used on the heart, the solution must be adequately cooled. Improper cooling may lead to a phenomenon known as calcium paradox, which can result in damage to cardiac muscle cells.

This medication should be stored in a cool place away from direct sunlight, at a temperature between 8 to 15 degrees Celsius. This helps safely maintain the efficacy of the medication.

Appearance

A pale yellow transparent solution

Package unit

6 packs/box [(1000ml/pack)], 2 packs/box [(5000ml/pack)]