Medication info

Veriplast-P Combi Set 3 mL

Prescription medicationSolution외용
Ingredient · strength
Human Fibrinogen›270mgHuman Plasma-Derived Coagulation Factor XIII›Strength being verifiedAprotinin Solution›Strength being verifiedHuman Thrombin›Strength being verifiedCalcium Chloride›17.7mg
Manufacturer / importer
대한적십자사
Appearance
1. Vial 1: A colorless vial containing a white freeze-dried substance, which becomes almost colorless and turns into a transparent or slightly turbid solution when dissolved with the Aprotinin solution. 2. Vial 2: A colorless transparent liquid.
Packaging
1 set/box [2 freeze-dried vials + 2 liquid vials]
Approval status
Active

MFDS item code 200511097 · Approved 2005.08.17 · Insurance code 655300060

Summary

Main use
Surgical assistive (tissue adhesion, suturing, local hemostasis) effect
Who uses it
Adults
Adult use
Up to 8 ㎠: 1 mL of this medicine set Up to 24 ㎠: 3 mL of this medicine set Administer the prepared solution (vial 1, vial 3) locally to the necessary tissue. - Apply the fibrinogen solution to the tissue area that needs joining and immediately sprinkle thrombin solution over it. - The area must be held in place for a few minutes until temporary adhesion occurs. Use the Pantaject set for simultaneous administration.

Ingredients

Importer
대한적십자사

Efficacy & effects

Surgical assistive (tissue adhesion, suturing, local hemostasis) effect

View approved original text

This medication is used when existing treatments are difficult to manage or insufficient. It is especially used as an assist in various surgical fields such as general surgery, cardiac surgery, thoracic surgery, pediatric surgery, neurosurgery, orthopedics, plastic surgery, trauma, obstetrics and gynecology, urology, otolaryngology, dentistry, maxillofacial surgery, and ophthalmology, helping to adhere tissues, suture, and assist in local hemostasis. This effectively controls bleeding at the surgical site and promotes wound healing. Such support increases the safety and success rate of surgeries and contributes to patient recovery. Thus, it plays an important supportive role in various surgical operations.

How to use

Adult use

Up to 8 ㎠: 1 mL of this medicine set Up to 24 ㎠: 3 mL of this medicine set Administer the prepared solution (vial 1, vial 3) locally to the necessary tissue. - Apply the fibrinogen solution to the tissue area that needs joining and immediately sprinkle thrombin solution over it. - The area must be held in place for a few minutes until temporary adhesion occurs. Use the Pantaject set for simultaneous administration.

Precautions

Since this medication is made from human blood, the risk of transmission of viruses or infections through blood cannot be completely eliminated. Therefore, it is advisable for hemophilia patients or those with severely weakened immunity to receive vaccinations such as the hepatitis A vaccine. Patients with severe bleeding or allergies to the components of this medication should not use it, and injecting it directly into the blood vessels is very dangerous and must be avoided. This medication should only be used at the wound site, and care should be taken as it can lead to life-threatening thrombosis or embolism if it accidentally enters the bloodstream. Allergic reactions such as hives, difficulty breathing, hypotension, or in severe cases, anaphylactic shock may occur; if these symptoms arise, stop using it immediately and inform medical personnel. When used for treating gastrointestinal bleeding via endoscopy, tissue damage or hematoma may occur, so symptoms such as abdominal pain, nausea, or vomiting should be checked for pancreatitis. Inform your doctor or pharmacist of any side effects, and be sure to protect body parts other than the treatment area from being contaminated with the medication. As this is a medication derived from human blood, various safety measures are taken to reduce the risk of viral infection, but it cannot be completely eliminated. The safety of this medication during pregnancy or breastfeeding has not been fully established, so it should only be used when the benefit outweighs the risk. This medication must strictly be used for local application only and should not be mixed with other medications, and the prepared solution should be used immediately. Store it in a sealed container so that air does not enter, and it should be kept in a refrigerator at a temperature between 2 degrees and 8 degrees. It is crucial not to freeze it, and to store it in its original outer box to prevent light from degrading its efficacy.

Side effects and when to seek care immediately

Serious side effects

  • Hives
  • decreased blood pressure
  • anaphylaxis
  • thrombosis
  • edema
  • wheezing
  • severe allergic reactions
  • anaphylactic reactions
  • shock
  • thromboembolic complications
Show 2 more
  • acute allergic reactions
  • intravascular coagulation reactions

Mild side effects

  • Facial flushing
  • nausea
  • vomiting
  • localized hives
  • chest tightness
  • hypotension
  • nausea
  • vomiting

Not everyone experiences these, and they can vary from person to person.

Storage

This medication should be stored in a sealed container to prevent air from entering, at refrigeration temperatures between 2 to 8 degrees. It is important not to freeze it, and since exposure to light may damage the efficacy of the medication, it is advisable to store it in its original outer box.

Appearance and packaging

Appearance

1. Vial 1: A colorless vial containing a white freeze-dried substance, which becomes almost colorless and turns into a transparent or slightly turbid solution when dissolved with the Aprotinin solution. 2. Vial 2: A colorless transparent liquid.

Package unit

1 set/box [2 freeze-dried vials + 2 liquid vials]

Same-ingredient medicines

Even with the same ingredient, strength, dosage form and how it is taken can differ.

Even with the same ingredient, the dose and directions can differ by strength and dosage form. Talk to a doctor or pharmacist before switching from a medication you are already taking.

Questions about this medicine

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For anything that needs medical judgment, consult a doctor or pharmacist.

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This drug information is based on data provided by the Korea Ministry of Food and Drug Safety.
Consult a doctor or pharmacist for accurate dosage, administration, and usage instructions.