Wise Combi No. 1

Adult dosage

Open the partition immediately before administration to mix solutions A and B. The maximum dosage is 1 to 1.5 g of total amino acids per day per kg of body weight. The infusion rate should not exceed 1.0 mL per hour (corresponding to glucose 0.25 g/kg and amino acids 0.04 g/kg) and it is preferable to administer this through central veins over 12 to 24 hours.

Children's dosage

For children, the dosage and infusion rate should be adjusted accordingly.

This medication must be used only according to a doctor's instructions. If used in conjunction with calcium-containing preparations administered intravenously, precipitates may form when mixed with certain antibiotics, so do not use the same infusion apparatus concurrently. Patients with allergic reactions, specific elevated electrolyte levels, or significantly compromised kidney or liver function should not use this medication. Particularly, it is safest not to administer this medication to neonates and children under 2 years old. Patients with bacteremia, heart failure, diabetes, or pancreatic disorders should use this medication cautiously, as allergic reactions may occur. During administration, blood glucose, electrolytes, and liver and kidney functions should be frequently monitored to detect any unusual signs early and respond accordingly. This medication contains high concentrations of glucose, which may lead to side effects such as hyperglycemia or acidosis; if symptoms occur, appropriate treatment should be sought immediately. Pregnant or nursing women should use this medication cautiously, as its safety has not been established, and it should be used at the doctor's discretion. Elderly patients may have decreased bodily function, so it is necessary to slowly adjust the infusion rate and dosage. In case of overdose, there is a risk of acidosis, fluid overload, and electrolyte imbalances, so dosing methods and quantities must be strictly adhered to. This medication must be administered slowly via central veins, and peripheral vein drip infusion should be avoided. Injections should be performed under sterile conditions to prevent infection, and the state of the solution should be thoroughly checked before use. Once opened, use quickly, and any unused remaining solution or apparatus should not be reused and must be disposed of. Store this medication in a sealed container to prevent contact with air, and it is recommended to store it at room temperature between 1 and 30 degrees Celsius. Proper storage will help maintain the efficacy of the drug.

Serious side effects

Urticaria, severe swelling (edema), pallor, severe allergic reactions, respiratory distress, asthma attacks, breathing difficulties, liver function abnormalities (including symptoms related to jaundice), severe edema or abnormal urination (notably reduced urine output and general swelling, including elevated blood pressure), severe neurological symptoms (severe headaches, seizures, altered consciousness, vision problems, paralysis, etc.), severe dermatological reactions (severe rashes, blistering, desquamation, with fever, etc.)

Mild side effects

• Acidosis
• cerebral edema
• pulmonary edema
• peripheral edema
• water intoxication
• hyperglycemia
• hyperosmotic diuresis
• thirst
• mild abnormalities in AST and ALT
• hyperkalemia

This medication should be stored in a sealed container to avoid contact with air, ideally at room temperature between 1 and 30 degrees Celsius. Storing it this way helps maintain the drug’s effectiveness.

Appearance

A pale yellow transparent liquid filled in a transparent plastic container separated by internal partitions.

Package unit

1000mL/box