Rivaron Tablet (Tibolone)

Adult dose

This medication is taken as 1 tablet once daily at the same time each day. No dosage adjustment is required for the elderly. Tablets should be taken with water or another beverage and it is recommended to take it at the same time each day.

This medication must not be administered to pregnant or breastfeeding women. Use is contraindicated in patients with or suspected of having breast cancer or estrogen-dependent malignant tumors or in those with a history of such conditions. Do not use in patients with unexplained vaginal bleeding or untreated endometrial hyperplasia. Patients with a previous history of venous thromboembolism or thromboembolic disease, as well as those with a history of arterial thromboembolic disease, may be at risk when taking this medication. It should not be administered to patients with acute liver dysfunction or liver disease that has not recovered to normal. If there is an allergy to any component or excipient of this medication, patients with porphyria or lactose intolerance should also avoid taking this medication. Symptoms such as liver function deterioration, increased blood pressure, or migraine may occur; administration should be stopped immediately if these symptoms arise. Caution should be exercised in patients with uterine fibroids, endometriosis, risk factors for thromboembolism, hypertension, liver disease, diabetes, cholelithiasis, migraine, systemic lupus erythematosus, history of endometrial hyperplasia, epilepsy, asthma, and otosclerosis during the use of this medication. Possible side effects during the use of this medication include lower abdominal pain, skin changes, abnormal hair growth, acne, increased vaginal discharge, increased endometrial thickness, breast tenderness, vaginal bleeding, pelvic pain, and vulvar itching. Additionally, dizziness, rash, headache, depression, edema, muscle pain, and abnormal liver function have also been reported. This medication may increase the risk of breast cancer, endometrial cancer, ischemic stroke, ovarian cancer, venous thromboembolism, and coronary artery disease; therefore, women with risk factors require thorough consultation and examination before use. Since this medication can affect blood coagulation, caution and dosage adjustments of anticoagulants such as warfarin are necessary when taken in combination. There may also be interactions with some medications, so it is important to inform the doctor or pharmacist of any medicines being taken. Women who are pregnant or planning to become pregnant should not take this medication, and if pregnancy is confirmed while taking this medication, it should be stopped immediately. Breastfeeding women should also not use this medication. In case of overdose, symptoms such as vomiting, nausea, and vaginal bleeding may occur, and there is no specific antidote; treatment should be symptomatic. This medication should be kept out of the reach of children and stored in its original package.

Serious side effects

Jaundice or liver function deterioration, significant increase in blood pressure, headache with migraine features, endometrial cancer, ischemic stroke, venous thromboembolism (deep vein thrombosis, pulmonary embolism), myocardial infarction, severe allergic reactions related to thrombus formation (e.g., hives, severe swelling, chest tightness, difficulty breathing, cold sweat, pallor), severe skin reactions (severe rashes with fever, blisters, skin peeling, oral/ocular mucosal involvement).

Mild side effects

Lower abdominal pain, abnormal hair growth, acne, vaginal discharge, increased endometrial wall thickness, postmenopausal bleeding, breast tenderness, vulvar itching, vaginal candidiasis, vaginal bleeding, pelvic pain, cervical dysplasia, genital discharge, vulvovaginitis, breast discomfort, fungal infection, vaginal fungal infection, nipple pain, weight gain, dizziness, rash, itching, seborrheic dermatitis, headache, migraine, visual disturbances (including blurred vision), gastrointestinal symptoms.

This medication should be stored in a tightly closed container to protect it from air or moisture, and it is advisable to keep it at a temperature below 25 degrees Celsius. Proper storage will maintain the medication's effectiveness and ensure safe use.

Appearance

White round tablet

Package unit

28 tablets/PTP