Huons Articaine Epinephrine Injection 1/100,000

Adult administration

Administer via local injection into the oral mucosa or into the local area. Conduct an aspiration test to ensure it does not enter the bloodstream. The injection rate should not exceed 1mL per minute. For general procedures, the recommended dosages vary depending on the procedure: infiltration 0.5–2.5mL, nerve block 0.5–3.4mL, oral surgery 1.0–5.1mL. A maximum of 7mg of articaine hydrochloride per kg of body weight should not be exceeded.

Child administration

Determine the anesthetic dosage based on age, weight, and type of procedure. The average dosage of articaine hydrochloride (mg) is calculated as child’s weight × 1.33. The maximum dosage should not exceed 5mg of articaine hydrochloride per kg of body weight.

This medication should not be administered via intravenous injection. If mistakenly injected intravenously, severe seizures, central nervous system and cardiac respiratory function impairment may occur, potentially leading to respiratory failure. When using this medication, resuscitation equipment and oxygen supply devices must be prepared in case of emergencies. Patients with hypertension or diabetes should be cautious when using this medication due to the risk of local tissue necrosis. Do not administer this medication to patients with known allergies to this drug, amide type local anesthetics, or its components. Particularly, patients allergic to sodium metabisulfite may experience severe allergic reactions such as anaphylaxis, so administration should be avoided. It should not be used in patients with cardiac conduction disorders not compensated by a pacemaker, those with intermittent acute porphyrias, uncontrolled epilepsy, children under 4 years old, patients contraindicated for concomitant use with guanethidine and similar drugs, those with cardiovascular disease, hyperthyroidism, uncontrolled severe diabetes, myasthenia gravis, patients concomitantly taking monoamine oxidase inhibitors or tricyclic antidepressants, or those likely to require general anesthesia. For patients on anticoagulants, there may be an increased risk of bleeding, so careful administration is required. Special care is needed for patients with cardiovascular issues, such as those with arrhythmias, coronary insufficiency, severe hypertension, and those with liver dysfunction, as drug metabolism may slow, leading to toxicity; dosage adjustments may be necessary. Dosages should also be reduced for patients with hypoxia, hyperkalemia, or metabolic acidosis. Patients with a history of epilepsy or lung diseases, particularly allergic asthma, should exercise caution due to the potential for allergic reactions to the components of this medication. Hyperthyroidism and diabetic patients are not recommended to use this medication because of the adrenaline component. Patients taking phenothiazine agents should be careful as combined use may reduce the vasoconstrictive effects of this medication. Patients on non-selective beta-blockers should also be cautious due to the risk of increased blood pressure. When using this medication, it is important to confirm the patient's constitution and allergy history, and to conduct a test injection in small amounts if there is a risk of allergy. When injecting, it is critical to inject slowly to avoid intravascular administration, and to continuously communicate with the patient to detect adverse reactions early. It is recommended not to inject into infected or inflamed areas, and to refrain from eating until normal sensation in the anesthetic area is restored. This medication may yield a positive result in doping tests, so athletes should be informed about this. It is contraindicated for combination with certain medications such as guanethidine, and caution is required when used with some antidepressants and monoamine oxidase inhibitors. During pregnancy, due to insufficient confirmation of safety for the fetus, this medication should only be used when its benefits outweigh the risks; caution is also needed during breastfeeding. This medication may affect reaction ability when driving or operating machinery, so caution is advised. In case of overdose, immediate oxygen supply and airway management are necessary; if seizures persist, anticonvulsants should be administered, and intubation may be needed as necessary. Finally, this medication must have its septum disinfected with alcohol before use, it should not be submerged in liquid or mixed with other drugs, and cartridges should not be reused after use.

Serious side effects

• Respiratory failure
• myocardial depression
• cardiac arrest
• angina
• rapid arrhythmias
• palpitations
• anaphylactic shock

Mild side effects

Headache, abnormal sensations in the lips or tongue (numbness, burning sensation, and tingling), reduced sensation, tremors, pathological talkativeness, metallic taste, dizziness, stupor, facial paralysis, drowsiness, nervousness, anxiety, restlessness, confusion, agitation, increased respiratory rate, yawning, rapid pulse, slow pulse, hypotension, hypertension, double vision, pupil dilation, eyelid droop, pupil constriction, enophthalmos, eye twitching, tinnitus, nausea, vomiting, diarrhea, facial swelling, itching

Store this medication in a container that does not allow light, as it is sensitive to light. It is crucial to store it in a cool place, maintaining a storage temperature between 1 and 25 degrees Celsius, and avoiding extremely hot or cold places.

Appearance

A colorless ampoule injection with a colorless cartridge filled with a clear liquid.

Package unit

- For domestic use: 1.7mL x 50 cartridge-type ampoules - For export: 1.7mL x 100 cartridge-type ampoules