Pelopinz Sustained Release Tablet (Pelodipine)

Adult dose

Swallow this medicine whole with water; do not divide, chew, or crush it. 1. Hypertension Administer felodipine orally at an initial dose of 5㎎ once daily and a maintenance dose of 5-10㎎ once daily in the morning. Do not exceed 20㎎ per day. This medicine may be administered concomitantly with a β-blocker or diuretic, and may be administered as monotherapy if other antihypertensive agents are unsuitable. Adjust the dose according to the patient's response to treatment. 2. Stable angina Administer an initial dose of 5㎎ once daily; the dose may be increased to 10㎎ if necessary. This medicine may be administered concomitantly if an adequate effect is not achieved with a β-blocker. Adjust the dose according to the patient's response to treatment. 3. Older adults Consider administering an initial dose of 2.5㎎ once daily and use with caution while monitoring the patient's condition. 4. Patients with renal impairment Renal impairment does not affect the plasma concentration of felodipine. No dose adjustment is necessary, but use with caution in patients with severe renal impairment (GFR<30ml/min). 5. Patients with hepatic impairment The plasma concentration of felodipine may be increased in patients with hepatic impairment, and they may respond to treatment at a lower dose. Therefore, consider administering an initial dose of 2.5mg once daily and use with caution in patients with hepatic impairment; do not administer to patients with severe hepatic impairment.

Child dose

The safety and efficacy in children have not been established.

This medication should not be used by women who are pregnant or may become pregnant. It is also recommended to avoid administration to patients in a state of cardiogenic shock or with severely impaired cardiac function. Additionally, patients who have previously shown allergic reactions to this medication should avoid its use. Those with aortic stenosis or mitral stenosis should be cautious as this medication may excessively lower blood pressure. It is advisable not to administer this medication to patients with severe liver dysfunction or those experiencing acute myocardial infarction or unstable angina. This medication contains lactose, so patients with lactose intolerance or certain genetic metabolic disorders should avoid it. Elderly patients and those with heart failure, hypotension, or compromised liver or kidney function should use this medication cautiously, and caution is also necessary for patients with a history of allergies. Initial doses or increases in dosage may cause symptoms such as flushing of the face, headache, palpitations, dizziness, and fatigue. Cardiac symptoms may include chest tightness, shortness of breath, and ankle swelling, so monitoring of the condition is important. Additionally, gastrointestinal symptoms such as nausea, constipation, abdominal pain may occur and, rarely, increased liver enzymes, skin rashes, itching, and muscle pain may develop. Abrupt discontinuation of this medication may worsen symptoms; therefore, the dosage should be gradually reduced according to the physician's instructions, taking care to avoid dizziness from excessively low blood pressure, which may require avoiding driving or dangerous tasks. It is best to take this medication on an empty stomach or after a light meal in the morning. If taken with other antihypertensives or specific antibiotics, antifungals, or anticonvulsants, the efficacy of this medication may change, so it is essential to inform the physician. Taking with grapefruit juice may increase the concentration of the medication, so it is advisable to avoid it. Pregnant or breastfeeding women should not use this medication, and it is recommended that breastfeeding be discontinued if using this medication. Safety for children has not been fully established, so it is preferable not to use it. It is advisable for the elderly to start with a lower dose and closely monitor their condition. In the case of overdose, severe hypotension, arrhythmias, or altered consciousness may occur, requiring immediate emergency treatment. If dizziness or fatigue occurs during use, it is advised to refrain from driving or operating machinery.

• Facial flushing
• headache
• palpitations
• dizziness
• fatigue
• tachycardia
• sensation of suffocation
• chest tightness
• ankle edema
• angina

This medication is sensitive to light, so it should be stored in a tightly sealed container that is protected from light. Additionally, it is best to store it at a temperature between 1 to 30 degrees Celsius at room temperature. Proper storage will help maintain the medication's effectiveness.

Appearance

Pale pink round film-coated tablet

Package unit

100 tablets/bottle, 30 tablets/bottle