Youngil Clopidogrel Tablet (Clopidogrel Sulfate)

Adult dose

1. For patients with ischemic stroke, myocardial infarction, or peripheral arterial disease, 75 mg of clopidogrel is administered orally once daily. 2. For patients with acute coronary syndrome (unstable angina or non-Q-wave myocardial infarction), it is recommended to start with a loading dose of 300 mg on the first day of administration, followed by a maintenance dose of 75 mg once daily. During this time, aspirin 75 to 325 mg should be administered alongside this medication once daily.

This medication works by inhibiting platelet aggregation to prevent blood clotting. Individuals with genetically reduced function of a specific enzyme (CYP2C19) may experience reduced effectiveness of this medication, and in such cases, treatment strategies should be reconsidered. Coadministration of this medication with drugs that activate CYP2C19 can increase the concentration of this medication and raise the risk of bleeding, hence coadministration is not recommended. Individuals who are allergic to this medication or its components, those with bleeding disorders, patients with severe liver damage, and nursing mothers should not take this medication. Additionally, those with genetic diseases that prevent the digestion of lactose or allergies to soybean oil, beans, or peanuts should avoid this medication. Patients at high risk of bleeding or suspected of having bleeding symptoms should inform their doctors immediately, and if surgery is planned, it is advisable to discontinue this medication 5 to 7 days prior to the procedure. Coadministration with other antiplatelet agents, anticoagulants, nonsteroidal anti-inflammatory drugs (NSAIDs), selective serotonin reuptake inhibitors (SSRIs), etc., may increase the risk of bleeding, thus caution is necessary. For pregnant women, although there is not significant impact on the fetus, the risk of bleeding during childbirth may increase, so discontinuing this medication 5 to 7 days before delivery is recommended. For nursing mothers, it is uncertain whether this medication is excreted in breast milk, and they should consult their doctor regarding discontinuation of breastfeeding or this medication. Safety in children has not been established, thus it is advisable not to administer it to pediatric patients. Elderly individuals or patients with impaired kidney and liver function may have an increased risk of bleeding, requiring dosage adjustment and careful monitoring. Overdosage may lead to severe bleeding and there is no antidote to reverse the effects of this medication; platelet transfusion may be required in case of severe bleeding. This medication should be stored out of reach of children, and it is safer not to transfer it to another container. If any adverse symptoms such as bleeding, skin rash, difficulty breathing, severe abdominal pain, or persistent headache occur during use, immediate medical attention is required.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe allergic reactions, severe rash with fever, blisters, skin peeling, oral/ocular mucosal pain, severe skin adverse reactions, shortness of breath or difficulty breathing, asthma attacks, respiratory issues accompanied by cough and fever, respiratory problems, jaundice (yellowing of skin or eyes), extreme fatigue, hepatic abnormalities (jaundice), sudden onset

Mild side effects

• Headache
• dizziness
• abdominal pain
• indigestion
• diarrhea
• nausea
• fatigue
• rash
• itching
• petechiae/bruising

This medication may be sensitive to air and moisture, thus it should be stored in a tightly sealed container. Additionally, it is recommended to store the medication at room temperature between 1 degree to 30 degrees Celsius. This will help maintain the medication's efficacy.

Appearance

Pink round film-coated tablet

Package unit

Bottle packaging - 30 tablets/bottle, Bottle packaging - 100 tablets/bottle