Apidexil Tablet 10 mg (Donepezil Hydrochloride Hydrate)

Adult dose

As Donepezil Hydrochloride, administer 5 mg once daily before bedtime. For 4 to 6 weeks, the 5 mg dose should be administered, and based on clinical response during this period, the dose can be increased to 10 mg. When increasing to 10 mg once daily, care should be taken regarding gastrointestinal adverse reactions. Underweight females over 85 years of age should not exceed 5 mg per day.

Child dose

There is no experience in using this medication in children.

This medication should not be used by individuals who are allergic to certain ingredients or by women who are pregnant or breastfeeding. Patients with a history of heart disease, peptic ulcers, asthma, chronic obstructive pulmonary disease, or extrapyramidal disorders such as Parkinson's disease should use this medication with caution. This medication may cause slow heart rates or arrhythmias, and there is a risk of gastrointestinal bleeding or ulcers. Serious side effects such as liver dysfunction, cerebrovascular problems, motor function impairment, and severe muscle cramps may occur, so if any symptoms arise, the doctor should be consulted immediately. While this medication may help improve dementia symptoms, side effects such as nausea, vomiting, diarrhea, dizziness, and insomnia may occur frequently. During treatment, the patient's condition should be regularly monitored to assess effectiveness and side effects, and to determine if discontinuation is necessary. Patients with heart disease or electrolyte imbalances need to have their heart condition monitored. This medication may interact with other drugs, so it is essential to inform healthcare professionals of any other medications being taken. Special caution is warranted when taken with drugs affecting the heart, antibiotics, or antidepressants. It is safest for pregnant or breastfeeding women to avoid using this medication, and consultation with a specialist is necessary if it is essential. Safety in children has not been established, and it is advisable not to use this medication in children. Caution is advised when driving or operating machinery, as dizziness or fatigue may occur. In cases of overdose, severe vomiting, sweating, abnormal heart rhythms, and breathing difficulties may occur, requiring immediate emergency treatment. This medication should be kept out of reach of children, and it is preferable not to transfer it to another container.

Serious side effects

Syncope, bradycardia, heart block, QT interval prolongation, myocardial infarction, heart failure, peptic ulcer, perforated duodenal perforation, gastrointestinal bleeding, hepatitis, liver dysfunction, jaundice, seizures (epilepsy, convulsions, etc.), cerebral hemorrhage, cerebrovascular disorders, extrapyramidal disorders (including severe symptoms), neuroleptic malignant syndrome, rhabdomyolysis, respiratory distress, acute pancreatitis, acute renal failure, unexplained sudden death, severe allergic reactions (urticaria).

Mild side effects

• Nausea
• vomiting
• loss of appetite
• diarrhea
• insomnia
• drowsiness
• headache
• fatigue
• muscle pain
• thrombocytopenia

This medication may be sensitive to air or moisture, so it should be stored in a sealed container. It is advisable to maintain the storage temperature between 1 and 30 degrees Celsius at room temperature to preserve the efficacy of the medication for a longer period.

Appearance

Yellow round film-coated tablet

Package unit

30 tablets/bottle