Donepezil (Memantine Hydrochloride)

Adult dose

Treatment must be initiated by a physician experienced in the diagnosis and management of Alzheimer's dementia, and it should only be started if a caregiver can regularly monitor the patient's medication intake. This medication can be taken without regard to meals. Dosage adjustment: The maximum daily dose is 20mg; to minimize the risk of adverse reactions, the following weekly increases should be made over the first three weeks to reach the maintenance dose: - First week (Days 1-7): Administer 5mg once daily for 7 days. - Second week (Days 8-14): Administer 10mg once daily (5mg twice daily) for 7 days. - Third week (Days 15-21): Administer 15mg once daily (10mg in the morning, 5mg in the evening) for 7 days. - From the fourth week: Administer 20mg (10mg twice daily). Maintenance dose: The recommended maintenance dose is 20mg once daily (10mg twice daily).

This medication should not be used in patients with known allergies to any of its components. Patients with severe hepatic dysfunction or significantly impaired renal function should not take this medication. Since this medication contains lactose, it should not be taken by patients with lactose intolerance or certain genetic metabolic disorders. Patients with a history of seizures or epilepsy should use this medication cautiously, as the risk of side effects may increase when taken with certain medications. Especially when taken with medications such as Amantadine, Ketamine, Dextromethorphan, the risk of central nervous system side effects may increase, so co-administration should be avoided. In cases of urinary infections or dietary changes that may affect renal function, the acidity of the urine should be carefully monitored. For patients with uncontrolled heart disease or hypertension, the safety of this medication has not been sufficiently established, so it should be used with caution. While taking this medication, side effects such as dizziness, headaches, constipation, drowsiness, and hypertension may occur; if symptoms are severe, consultation with healthcare professionals is recommended. This medication may interact with other drugs; therefore, patients taking antipsychotics, muscle relaxants, anticoagulants, etc., should inform their doctor. Pregnant women or those who may become pregnant should carefully consider the risks and benefits before taking this medication, and nursing mothers are advised to discontinue breastfeeding. Children and adolescents under 18 years of age should not use this medication as its safety and efficacy have not been established. In the case of an overdose, central nervous system symptoms such as confusion, drowsiness, hallucinations, and seizures may occur; if suspected, immediate medical consultation is required. Patients taking this medication should exercise caution when driving or operating machinery, as the reaction time may be slowed, and safety should be considered. Store the medication out of the reach of children, and keep it in its original packaging to maintain quality.

Serious side effects

• Seizures
• psychotic reactions
• dyspnea
• hepatitis
• heart failure
• venous thromboembolism

Mild side effects

• Dizziness
• headache
• constipation
• drowsiness
• hypertension
• confusion
• hallucinations
• psychotic reactions
• balance disorders
• gait abnormalities

This medication should be stored in a tightly sealed container to prevent exposure to air or moisture, and it is best stored at room temperature between 1 to 30 degrees Celsius. Proper storage will maintain the medication's efficacy and prevent degradation.

Appearance

White oval film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle