Crisin Solution (Clindamycin Phosphate)

Adult administration

(Injection) For severe infections, administer clindamycin phosphate 600-1200 mg divided into 2-4 doses by intravenous or intramuscular injection. For very severe infections, administer 1200-2700 mg divided into 2-4 doses. In emergencies, the daily dose can be increased to 4.8 g for intravenous injection. Injections should not be administered directly as a bolus into the vein but should be infused over a period of 10-60 minutes. Depending on the targeted serum concentration, adjustments may be needed.

Child administration

(Injection) For children over 1 month old, administer 15-25 mg per kg of body weight for severe infections divided into 3-4 doses by intravenous or intramuscular injection. For very severe infections, administer 25-40 mg per kg of body weight divided into 3-4 doses.

This medication is used to treat severe infections and can sometimes cause serious colitis; it should only be used when treatment with other antibiotics is difficult. If colitis occurs, symptoms such as severe diarrhea, abdominal pain, and fever may appear, so it is essential to stop administration immediately or observe carefully if symptoms are severe. It is advisable not to use this medication for non-bacterial upper respiratory infections or mild bacterial infections. This medication does not penetrate well into cerebrospinal fluid and is not suitable for treating meningitis. When opening the injection container, glass fragments may be mixed, so caution should be exercised, especially when administering to children or the elderly. Patients who are allergic to lincomycin or clindamycin should not use this medication. Elderly patients, weakened individuals, patients with liver or kidney impairment, individuals with atopic constitution or asthma, and those with myasthenia gravis should use this medication cautiously. Injection may cause pain or numbness at the injection site for muscle injections, and thrombophlebitis may occur for intravenous injections; hence, care should be taken with the injection method. Gastrointestinal side effects may include diarrhea, abdominal pain, nausea, and vomiting, and in severe cases, pseudomembranous colitis may occur. Allergic reactions can manifest as hives, rashes, difficulty breathing, and low blood pressure, so if unusual symptoms occur, administration should be discontinued immediately. Liver or kidney dysfunction may occur, so regular function tests should be performed during long-term use. This medication can enhance muscle relaxant effects when used concurrently, so caution is necessary during combination. Pregnant women or those who may become pregnant and breastfeeding women are advised not to use this medication. Safety has not been established in newborns, premature infants, or children, so it should be administered cautiously only when necessary, and regular check-ups of liver and kidney function are recommended. In the case of overdose, there is no specific antidote, so emergency treatment must be done according to symptoms, and it is not removed by hemodialysis. This medication should be stored out of reach of children in a tightly closed container, and it is advisable to use it as soon as possible after opening.

Serious side effects

Severe colitis, pseudomembranous colitis, severe diarrhea accompanied by fever and blood in the stool, hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, paleness, generalized flushing, cyanosis, respiratory distress, chest discomfort, low blood pressure, Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme, skin peeling, pain in mucous membranes of the mouth/eyes, jaundice of skin and eyes, liver function impairment, acute renal failure, reduced urine output, high blood pressure.

Mild side effects

Pain, numbness at the injection site, thrombophlebitis, diarrhea, soft stools, loss of appetite, nausea, vomiting, abdominal pain, esophagitis, glossitis, stomatitis, generalized flushing, hives, cyanosis, chest discomfort, low blood pressure, wheal-and-flare reactions, erythema, measles-like skin rash, edema, itching, vaginitis, desquamation and vesiculobullous dermatitis, angioedema, Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme, increased ALT, AST, ALP levels, BU.

This medication must be stored in a tightly closed container to prevent exposure to air and moisture. Maintaining a storage temperature between 1 degree and 30 degrees Celsius is essential. This way, the effectiveness of the medication can be preserved for a longer period.

Appearance

A colorless topical solution with a peculiar odor

Package unit

30 grams/bottle, 45 grams/bottle