Anadip Tablets 10 Milligrams (Lercanidipine Hydrochloride)

Adult dose

Lercanidipine Hydrochloride: The recommended dose is 5 to 10 mg orally once daily at least 15 minutes before a meal. The dose may be increased to 20 mg based on patient symptoms. Dose adjustment takes about 2 weeks to observe maximum antihypertensive effect, and should be done gradually. Patients whose blood pressure is not controlled with this medication may receive adjunct therapy with beta-blockers (such as atenolol), diuretics (such as hydrochlorothiazide), or ACE inhibitors (such as captopril, enalapril). The dose-response curve is steep, and it reaches a peak at doses of 20 to 30 mg, so administering doses higher than this may not increase effectiveness but may instead increase adverse reactions. ○ Elderly patients: Although pharmacokinetic data and clinical experience suggest that dose adjustment is not required, caution is needed when initiating treatment in elderly patients. ○ Liver and kidney impairment: Special caution is required during initiation in patients with mild to moderate liver or kidney impairment. Although the usual dosage pattern for these patients is stable, caution is required when increasing the dosage to 20 mg/day. In patients with liver impairment, the antihypertensive effect may be enhanced, and dose adjustments should be considered. This medication is contraindicated in patients with severe liver or kidney impairment.

This medication should not be administered to certain patients. For example, those with an allergy to this medication or similar drugs, pregnant or breastfeeding women, patients with left ventricular outflow obstruction, untreated congestive heart failure, unstable angina, severe liver or kidney impairment, patients who have recently experienced acute myocardial infarction, patients undergoing dialysis, children or adolescents under 18 years of age, and those with genetic lactose intolerance problems should not use this medication. Additionally, this medication should be carefully administered to some patients with cardiovascular problems, mild to moderate kidney or liver dysfunction, a history of angina, frequent alcohol consumption, and especially elderly patients. When taking this medication, various side effects may occur. Symptoms such as facial flushing, peripheral edema, palpitations, headaches, dizziness, fatigue, indigestion, nausea, vomiting, abdominal pain, and diarrhea can appear. Regular liver function tests are necessary, as liver function abnormalities may develop, and gingival hyperplasia may also occur, requiring monitoring. Skin rashes and myalgia have also been reported. This medication may worsen symptoms if suddenly discontinued, so it should be tapered off gradually under a physician's guidance. Caution is also needed while driving or operating machinery, as dizziness or drowsiness may occur. This medication is metabolized by a specific enzyme (CYP3A4) in the liver, so taking it alongside other medications that inhibit or activate this enzyme may alter its effect. For instance, taking antifungals, certain antibiotics, immunosuppressants, anticonvulsants, and grapefruit juice can increase blood concentration and the risk of side effects; hence caution is required. Moreover, alcohol consumption can enhance the vasodilatory effects of this medication, increasing the risk of hypotension, so it is advisable to avoid it. Pregnant or potentially pregnant women and nursing mothers should not use this medication. Animal studies have documented negative effects on fetuses when high doses are administered, and there is a possibility that it could be excreted in breast milk. Safety and efficacy have not been established for children or adolescents under 18 years of age, so it is not used in this population. Elderly patients may experience different drug metabolism and responses; therefore, special caution is needed during initial administration. In the case of overdose, severe hypotension, rapid heart rate, drowsiness, and cardiac shock can occur; immediate medical attention is required, and cardiovascular status should be monitored for at least 24 hours. Blood dialysis may not effectively remove this medication. Lastly, this medication should be kept out of reach of children, and transferring it to other containers can adversely affect the quality of the drug, so caution should be exercised.

Serious side effects

• Chest pain
• angina
• cold sweat
• shortness of breath
• liver dysfunction

Mild side effects

• Flushing
• peripheral edema
• palpitations
• tachycardia
• headache
• dizziness
• weakness
• fatigue
• drowsiness
• neurasthenia

This medication is sensitive to air and humidity; therefore, it must be stored in a tightly sealed container. It is important to maintain a storage temperature between 1 and 30 degrees Celsius.

Appearance

Yellow round film-coated tablets

Package unit

30 tablets/bottle