Medication info
Proverin Tablets (Propiverine Hydrochloride)

Proverin Tablets (Propiverine Hydrochloride)

Prescription medicationTabletOral
Ingredient · strength
Propiverine Hydrochloride›20mg / 1 tablet
Manufacturer / importer
Hanaol Bio Pharma Co., Ltd.
Appearance
White round film-coated tablets, odorless
Packaging
30 tablets/bottle, 100 tablets/bottle
Approval status
Active

MFDS item code 200500473 · Notified 2005.02.28 · Insurance code 655602050

Summary

Main use
Relief of symptoms of overactive bladder (e.g., urgency), urinary frequency, and urinary incontinence (e.g., neurogenic bladder)
Who takes it
Adults
Adult dose
Adults: Administer propiverine hydrochloride 20 mg orally once daily after a meal. Adjust the dose as appropriate according to symptoms; if the effect is insufficient and there are no safety concerns, 20 mg may be taken up to twice daily.

Ingredients

Manufacturer
Hanaol Bio Pharma Co., Ltd.

Efficacy & effects

Relief of symptoms of overactive bladder (e.g., urgency), urinary frequency, and urinary incontinence (e.g., neurogenic bladder)

  • Frequent urination
  • incontinence
  • neurogenic bladder
  • neurogenic polyuria
  • unstable bladder
  • bladder irritative condition
  • chronic cystitis
  • chronic prostatitis
  • urinary urgency
  • urge incontinence
View approved original text

This medication is used for various bladder-related disorders. It helps improve frequent urination and incontinence caused by neurogenic bladder or neurogenic polyuria. It is also effective for unstable bladder and bladder irritative conditions due to chronic cystitis and chronic prostatitis. It alleviates symptoms by controlling urgency, frequency, and urge incontinence associated with overactive bladder. Overall, it is used to help stabilize bladder function and improve symptoms.

How to take

Adult dose

Adults: Administer propiverine hydrochloride 20 mg orally once daily after a meal. Adjust the dose as appropriate according to symptoms; if the effect is insufficient and there are no safety concerns, 20 mg may be taken up to twice daily.

Precautions

This medication should not be administered to certain patients. Patients who have had allergic reactions to this medication or its components should not use it. Additionally, it should not be administered to patients with gastric or intestinal obstructions, as it may worsen symptoms in patients with weak gastric or intestinal motility. It should also be avoided in patients who have difficulty urinating, glaucoma, severe myasthenia gravis, or heart diseases, as it may worsen symptoms. Patients with genetic issues like lactose intolerance should not take this medication. Patients with kidney or liver dysfunction, Parkinson's disease, or hyperthyroidism should exercise caution when using this medication. Elderly patients or those with autonomic nervous system diseases, heart diseases, cerebral infarction, or benign prostatic hyperplasia should also be treated with caution. Especially, patients with glaucoma should be careful as increased intraocular pressure may worsen their symptoms. This medication can cause severe side effects in various systems including the central nervous system, digestive system, and cardiovascular system. Symptoms such as hallucinations, incoherence, palpitations, constipation, abdominal distension, thrombocytopenia, renal dysfunction, skin rashes, increased intraocular pressure, liver abnormalities, muscle pain, etc. have been reported. If these symptoms occur, stop taking the medication immediately and seek medical attention. When taking this medication, a definitive diagnosis of the symptoms should be made, and it should be checked whether there are other conditions such as bladder cancer, prostate cancer, or urinary tract infections. Care should be taken when driving or operating machinery as drowsiness or dizziness may occur. Caution should also be exercised when taken with other anticholinergics, tricyclic antidepressants, phenothiazine medications, and MAO inhibitors, as side effects may increase. It is advisable for women who are pregnant or may become pregnant to avoid this medication, and breastfeeding women should also stop breastfeeding while taking it. The safety of this medication in children has not been established, so it is recommended not to administer it to them. Elderly patients may have reduced liver and kidney function, so it is important to start with a low dosage and administer it carefully. In cases of overdose, symptoms such as incoherence, seizures, gait disturbances, paralytic ileus, urinary retention, tachycardia, and increased blood pressure may occur, requiring gastric lavage and appropriate treatment. This medication should be kept out of reach of children, and transferring it to another container can adversely affect its quality, so caution is advised.

Side effects

  • Hallucinations
  • delusions
  • paralytic ileus
  • significant constipation
  • abdominal distension
  • palpitations
  • extrasystole
  • bradycardia
  • QT prolongation
  • ventricular tachycardia
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  • heart block
  • thrombocytopenia
  • renal impairment
  • urinary retention
  • Steven-Johnson syndrome
  • fever
  • erythema
  • itching
  • conjunctival injection
  • stomatitis
  • elevated intraocular pressure
  • acute angle-closure glaucoma attack
  • nausea
  • headache
  • vision impairment
  • liver dysfunction
  • jaundice
  • myalgia
  • weakness
  • rhabdomyolysis
  • thirst
  • constipation
  • abdominal pain
  • nausea
  • vomiting
  • dyspepsia
  • diarrhea
  • anorexia
  • stomatitis
  • glossitis
  • dysuria
  • residual urine
  • loss of urination sensation
  • dizziness
  • headache
  • numbness
  • drowsiness
  • insomnia
  • tremor
  • altered consciousness
  • perceptual disturbance
  • transient forgetfulness
  • Parkinsonian symptoms
  • abnormal involuntary movements
  • hypotension
  • hypertension
  • chest pain
  • hypersensitivity
  • itching
  • rash
  • urticaria
  • coordination disorder
  • dry eyes
  • elevated AST
  • elevated ALT
  • elevated ALP
  • elevated BUN
  • increased creatinine
  • leukopenia
  • fatigue
  • lethargy
  • edema
  • weakness
  • dysgeusia
  • low back pain
  • hoarseness
  • sputum
  • agitation
  • heat due to decreased sweating
  • weakness
  • pharyngalgia
  • delusions
  • agitation
  • generalized convulsions
  • gait disturbance
  • speech disturbance
  • mydriasis
  • paralytic ileus
  • urinary retention
  • tachycardia
  • hypertension
  • generalized flushing
  • hepatic impairment

Not everyone experiences these, and they can vary from person to person.

Storage

This medication may be sensitive to air or moisture, so it should be stored in a tightly sealed container. Moreover, it is advisable to store the medication at room temperature between 1°C and 30°C, away from extremely hot or cold areas.

Appearance and packaging

Appearance

White round film-coated tablets, odorless

Package unit

30 tablets/bottle, 100 tablets/bottle

Same-ingredient medicines

Even with the same ingredient, strength, dosage form and how it is taken can differ.

Even with the same ingredient, the dose and directions can differ by strength and dosage form. Talk to a doctor or pharmacist before switching from a medication you are already taking.

Questions about this medicine

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For anything that needs medical judgment, consult a doctor or pharmacist.

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This drug information is based on data provided by the Korea Ministry of Food and Drug Safety.
Consult a doctor or pharmacist for accurate dosage, administration, and usage instructions.