Rivaro Tablets 1 mg (Pitavastatin Calcium Hydrate)

Adult dose

For adults, the usual initial dose of Pitavastatin Calcium is 1-2 mg once daily. If the LDL cholesterol-lowering effect is insufficient, the dose may be increased to a maximum of 4 mg per day. Adjustments to the dose should be made every 4 weeks or more and maintained with continuous administration for therapeutic efficacy.

Child dose

For pediatric patients (10 to 16 years) with heterozygous familial hypercholesterolemia, administer Pitavastatin Calcium 1 mg once daily. If the LDL cholesterol-lowering effect is insufficient, increase to a maximum of 2 mg per day.

This medication should not be used in patients who have had allergic reactions to any of its components, patients with active liver disease, severe liver impairment or obstructed bile flow, and patients taking cyclosporine. Furthermore, it is contraindicated in women with myopathy, pregnant women or women who may become pregnant, and nursing mothers. This medication contains lactose; therefore, it should not be taken by patients with lactose intolerance or related genetic disorders. Caution is advised in patients with kidney dysfunction or a history of liver disorders, as well as individuals who consume excessive alcohol. In particular, it is advisable to avoid concomitant use with fibrates or niacin due to the risk of muscle injury and impaired kidney function. Elderly patients, children, those with hypothyroidism, and patients with genetic muscle disorders should be administered this drug with care, and special caution is needed in patients with severe myasthenia. During treatment, unusual symptoms such as muscle pain, weakness, abdominal pain, rash, itching, headache, myalgia, stiffness, drowsiness, insomnia, heavy feeling, dizziness, thirst, dyspepsia, abdominal bloating, constipation, stomatitis, vomiting, loss of appetite, glossitis, nausea, gastrointestinal discomfort, diarrhea, thrombocytopenia, granulocytopenia, leukopenia, eosinophilia, leukocytosis, glucocorticoid elevation, Coombs test positivity, anemia, increased urination, increased BUN, and elevated serum creatinine should be reported to healthcare providers immediately. Regular liver function tests are necessary, and the medication may need to be discontinued if liver enzyme levels rise. This medication can cause muscle damage (rhabdomyolysis); if muscle pain or weakness worsens, treatment should be ceased. Additionally, this drug may interact with other medications, particularly when used in conjunction with cyclosporine, fibrates, niacin, or erythromycin. Pregnant or nursing women should not take this medication, and women of childbearing potential should verify pregnancy status before use. In pediatric patients, it should be given cautiously under a specialist's guidance for the treatment of familial hypercholesterolemia, and safety has not been established in children under 10 years of age. This medication should be kept out of reach of children and stored in its original container. Before starting treatment, patients should appropriately implement non-drug therapies such as dietary changes and exercise, and the medication should be discontinued if no therapeutic effect is observed. Elderly patients may experience adverse reactions due to reduced physiological function, so dosage adjustments may be required. During treatment, there may be an increased risk of developing diabetes; therefore, blood glucose monitoring is essential. Long-term use may rarely lead to interstitial lung disease, so patients should immediately inform healthcare providers of any respiratory symptoms like shortness of breath or cough.

Serious side effects

Hives, rhabdomyolysis, liver dysfunction, jaundice, paralysis, severe allergic reactions, elevated blood pressure, severe swelling or urination abnormalities, severe skin reactions, serious neurological symptoms, difficulty breathing, respiratory issues

Mild side effects

• Abdominal pain
• rash
• fatigue
• numbness
• itching
• headache
• myalgia
• stiffness
• drowsiness
• insomnia

This medication is sensitive to light and should be stored in a dark container away from light. Additionally, it is best to store it at room temperature between 1 degree and 30 degrees Celsius. Proper storage will help maintain the drug's efficacy and safety.

Appearance

Round white film-coated tablet

Package unit

30 tablets (10 tablets/PTP × 3)