Donepezil 10 mg Tablet (Donepezil Hydrochloride Hydrate)

Adult dose

As donepezil hydrochloride, administer 5 mg once daily before bedtime. If unusual dreams, nightmares, or insomnia occur, consider morning administration. For 4 to 6 weeks, administer 5 mg before assessing clinical response, and it may be increased to 10 mg. When increasing to 10 mg daily, monitor for gastrointestinal adverse reactions. Underweight elderly women should not exceed 5 mg per day.

Child dose

There is no experience of using this medication in pediatric patients.

This medication contains donepezil hydrochloride as its active ingredient and is primarily used to treat symptoms of Alzheimer's type dementia. First, this medication should not be administered to certain patients. For example, individuals who are allergic to this medication or any of its components, pregnant women or women who may become pregnant, and nursing mothers should not take this medication. Additionally, since this medication contains lactose, patients with hereditary lactose intolerance or certain enzyme deficiencies related to lactose breakdown should also avoid this medication. Patients with heart disease or conduction disorders should be cautious, as the use of this medication may lead to heart-related adverse reactions such as bradycardia or arrhythmia. Those taking non-steroidal anti-inflammatory drugs or with a history of peptic ulcers should use this medication carefully, as increased gastric acid secretion may worsen their symptoms. Patients with a history of asthma or obstructive pulmonary disease should also be cautious, as bronchoconstriction or increased mucus secretion may exacerbate symptoms. Patients with extrapyramidal disorders such as Parkinson's disease should be careful, as the cholinergic effects of this medication may worsen their symptoms. This medication contains the dye Yellow No. 5, and those allergic to this component should use it with caution. During treatment with this medication, various adverse reactions may occur. Heart-related issues may include syncope, bradycardia, heart block, and myocardial infarction; gastrointestinal issues may include peptic ulcers, gastrointestinal bleeding, nausea, vomiting, and diarrhea. Central nervous system effects may include hallucinations, insomnia, dizziness, seizures, and confusion, and muscle-related adverse reactions may include myalgia, tremors, and movement disorders. Severe adverse effects such as liver dysfunction, acute pancreatitis, and acute renal failure have also been reported, so patients should consult their healthcare provider immediately if symptoms occur. This medication may affect the ability to drive or operate machinery, so caution is needed during initial use or when changing doses. Pregnant or nursing women are advised to avoid this medication, and if it must be taken, careful consideration should be given after consulting a healthcare professional. This medication may interact with other medications, so be sure to inform your doctor or pharmacist if combining with heart medications, antibiotics, antidepressants, or antipsychotic drugs. In case of overdose, serious symptoms such as nausea, vomiting, bradycardia, and respiratory depression may occur, necessitating immediate emergency treatment, and atropine may be used as an antidote. Lastly, this medication should be kept out of reach of children, and transferring it to other containers is not recommended as it may compromise quality.

Serious side effects

Syncope, bradycardia, heart block, QT interval prolongation, myocardial infarction, heart failure, peptic ulcers, perforated duodenal perforation, gastrointestinal bleeding, hepatitis, hepatic dysfunction, jaundice, cerebral seizures, cerebral hemorrhage, cerebrovascular disorders, extrapyramidal disorders (movement dysfunction, ataxia, movement disorders, abnormal muscle tone, tremors, involuntary movements, gait disturbances, abnormal posturing, speech disorders), neuroleptic malignant syndrome (stiffness, extreme rigidity, dysphagia,

Mild side effects

Nausea, vomiting, dizziness, diarrhea, insomnia, abdominal pain, loss of appetite, headache, fatigue, drowsiness, sweating, skin rash, aggressive behavior, tremors, gait disturbances, involuntary movements, decreased concentration, mental dullness, weakness, fever, decreased body temperature, hematologic abnormalities (decreased hematocrit, leukopenia, anemia, thrombocytopenia), muscle cramps, myalgia, urinary incontinence, frequent urination, urinary retention, toothache, facial flushing, malaise, falls, eczema, itching,

This medication should be stored in a tightly closed container to prevent air and moisture from entering. The storage temperature should be maintained between 1 degree and 30 degrees Celsius.

Appearance

Yellow round film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle