Pantheon Tablet 40 Milligrams (Pantoprazole Sodium Sesquihydrate)

Adult dose

1. Combination therapy with antibiotics to prevent recurrence of gastroduodenal ulcers infected with Helicobacter pylori - The usual adult dose is 40 mg of pantoprazole per dose, twice daily (before breakfast and dinner), in combination with the following antibiotics for 1 week. Swallow without chewing or crushing. (1) Take 1,000 mg of amoxicillin and 500 mg of clarithromycin per dose, twice daily for 1 week, or (2) Take 500 mg of metronidazole and 500 mg of clarithromycin per dose, twice daily for 1 week, or (3) Take 1,000 mg of amoxicillin and 500 mg of metronidazole per dose, twice daily for 1 week. - Regimens using metronidazole in (2) and (3) should be used only when regimen 1 is inappropriate. - If additional treatment with pantoprazole is indicated to ensure ulcer healing, the recommended doses for duodenal and gastric ulcers described below should be considered. - If combination therapy is not required (e.g., Helicobacter pylori-negative infection), use pantoprazole monotherapy according to the dosage instructions below. 2. Gastric ulcer and reflux esophagitis - The usual adult dose is 40 mg of pantoprazole once daily, taken with water before breakfast. Swallow without chewing or crushing. - Healing occurs within 4 weeks in most patients, although healing time may vary in some patients. If healing is incomplete after the initial 4 weeks, continue treatment for another 4 weeks. - If the patient has not responded to other treatments, the dose may be doubled to 80 mg of pantoprazole per day. 3. Duodenal ulcer - The usual adult dose is 40 mg of pantoprazole once daily, taken with water before breakfast. Swallow without chewing or crushing. - Healing occurs within 2 weeks in most patients, although healing time may vary in some patients. If healing is incomplete after the initial 2 weeks, continue treatment for another 2 weeks. - If the patient has not responded to other treatments, the dose may be doubled to 80 mg of pantoprazole per day. 4. Zollinger-Ellison syndrome and other pathological hypersecretory conditions - Start with an initial dose of 80 mg of pantoprazole per day, then increase or decrease the dose according to measurements of gastric acid secretion. - Doses above 80 mg should be divided into 2 daily doses. - The dose may be temporarily increased to 160 mg or more, but only for as long as needed to control acid secretion adequately. - There is no limit to the duration of treatment, but it should be changed as clinically necessary. ○ In patients with severe liver impairment, reduce the dose so that it does not exceed 20mg of pantoprazole once daily. ○ In older adults or patients with renal impairment, do not exceed 40 mg of pantoprazole per day. In older adults, as an exception, this medicine may be taken at a dose of 40 mg per dose, twice daily (before breakfast and dinner), in combination with the antibiotics listed above, for 1 week. Swallow without chewing or crushing. ○ Antibiotic combination therapy should not be used in patients with moderate to severe hepatic/renal impairment. Data on the efficacy and safety of this combination therapy are insufficient.

This medication should not be used in patients with moderate to severe liver or kidney dysfunction as its safety and efficacy have not been established. Patients with allergies to this medication, its components, or the benzimidazole class should not take it if they have experienced severe allergic reactions in the past. Caution should be exercised when using this medication with specific antibiotics if the patient is allergic to penicillin or macrolide antibiotics. Co-administration with specific heart medications may result in severe side effects; hence, this combination should be avoided. It is safer to avoid this medication in early pregnancy or in women of childbearing potential, as well as in nursing mothers unless directed by a specialist. Long-term use of this medication can lead to various side effects including liver dysfunction, gastrointestinal problems, and skin rashes; thus regular check-ups are required. This medication should only be used after proper diagnosis in cases where stomach cancer or severe gastrointestinal disease is suspected. Care should be taken as long-term use may lead to vitamin B12 absorption disorders. This medication might increase the risk of infection due to promotion of bacterial growth in the stomach by inhibiting gastric acid secretion. Dizziness or visual disturbances may occur; hence caution is needed while driving or operating machinery. This medication may interact with other drugs, particularly anticoagulants, antivirals, and immunosuppressants; consultation with a specialist is recommended. Pregnant or nursing women should avoid using this medication and consult a specialist if necessary. It is not recommended for adolescents or children under 18 years of age due to insufficient experience in usage. In case of overdose, there are no specific antidotes; symptomatic treatment should be provided. This medication should be swallowed whole and not chewed or crushed, and kept out of reach of children. Long-term use of this medication may result in gastrointestinal abnormalities such as gastric polyps, so the minimum effective dose for the shortest duration is recommended. If any abnormal symptoms appear during medication, immediate consultation with healthcare providers is required.

Upper abdominal pain, constipation, flatulence, diarrhea, nausea, vomiting, belching, dry mouth, fatigue, weakness, lethargy, edema, increased body temperature, fever, elevated liver enzyme levels, increased bilirubin, jaundice, anaphylactic shock, arthralgia, myalgia, rhabdomyolysis, bone fractures, headache, dizziness, visual disturbances, taste abnormalities, insomnia, sleep disturbances, depression, hallucinations, confusion, spatial disorientation, interstitial nephritis, pruritus, skin erythema, urticaria, angioedema, skin and mucous membrane syndrome, erythema multiforme, toxic epidermal necrolysis, photosensitivity, hyperglycemia, agranulocytosis, leukopenia, thrombocytopenia, pancytopenia, gynecomastia, hyperlipidemia, increased lipids, weight changes, hyponatremia, hypomagnesemia, elevated CK, anxiety, asthenia, low back pain, bronchitis, chest pain, increased cough, dyspepsia, dyspnea, flu-like symptoms, gastroenteritis, gastrointestinal disorders, overexcitement, infection, migraine, neck pain, pain, pharyngitis, rectal disorders, rhinitis, elevated AST, sinusitis, upper respiratory tract infection, frequent urination, urinary tract infection, boils, allergic reactions, chills, abscess, facial edema, general edema, heat sensations, hernia, abnormal laboratory results, lethargy, moniliasis, tumors, nonspecific drug reactions, abnormal ECG, angina, arrhythmia, atrial fibrillation, coronary artery disease, congestive heart failure, bleeding, hypertension, hypotension, myocardial infarction, myocardial ischemia, palpitations, retinal vascular disease, syncope, tachycardia, phlebitis, thrombosis, vasodilation, decreased appetite, aphthous stomatitis, colitis, duodenitis, swallowing difficulties, enteritis, esophageal bleeding, esophagitis, gastric-duodenal tumors, gastric-duodenal bleeding, gastric-duodenal moniliasis, gingivitis, halitosis, hematemesis, increased appetite, melena, oral ulcers, oral moniliasis, periodontal abscess, periodontitis, rectal bleeding, gastric ulcers, bowel irregularities, tongue discoloration, ulcerative colitis, diabetes, goiter, gallbladder pain, hyperbilirubinemia, cholecystitis, cholelithiasis, jaundice, hepatitis, elevated ALP, anemia, petechiae, eosinophilia, iron deficiency anemia, leukocytosis, leukopenia, thrombocytopenia, dehydration, gout, thirst, weight gain, weight loss, arthritis, bone disease, joint disease, leg cramps, bursitis, tendinitis, abnormal dream, confusion, seizures, dry mouth, speech disorder, hallucinations, hyperactivity, decreased libido, restlessness, neuralgia, neuritis, nervous disorders, dysesthesia, decreased reflexes, sleep disturbances, drowsiness, perceptual disturbances, tremors, asthma, epistaxis, hiccups, laryngitis, respiratory disorder, pneumonia, voice changes, acne, alopecia, contact dermatitis, eczema, fungal dermatitis, bleeding, herpes simplex, shingles, lichen planus dermatitis, papular eruption, skin disease, skin ulcers, sweating, amblyopia, cataract, hearing impairment, diplopia, ear pain, paralysis, glaucoma, otitis externa, taste abnormalities, tinnitus, albuminuria, balanitis, mastalgia, cystitis, menstrual irregularities, urination disorders, epididymitis, hematuria, erectile dysfunction, kidney stones, renal pain, nocturnal enuresis, prostate disorders, pyelonephritis, scrotal edema, urethral pain, urethral disorders, urological abnormalities, vaginitis, Clostridium difficile-associated diarrhea, DRESS syndrome, microscopic colitis, systemic lupus erythematosus, cutaneous lupus erythematosus, gastric polyp

This medication should be stored in a tightly closed container that protects it from light and at room temperature between 1°C and 30°C. Storing it this way will help maintain the medication's efficacy for a longer time.

Appearance

Yellow enteric-coated oval tablet

Package unit

28 tablets/bottle