JR Glimepiride Tablet

Adult dose

Adjust individually for each patient. Swallow without chewing, with more than 1/2 cup of water. Take once daily orally. Should be taken before breakfast or just before the first meal. The initial dose for monotherapy should start with 1 mg of glimepiride once daily and can be increased by 1 mg every 1 to 2 weeks. Generally, additional effects are minimal above 4 mg; however, some patients may require an increase to 6 mg or 8 mg.

This medication should not be used in patients with insulin-dependent diabetes or those in diabetic ketoacidosis or coma. Additionally, patients allergic to this medication or its components, sulfonylureas, or sulfonamide medications should not be prescribed this medication. This medication has not been used in patients with severe liver or kidney dysfunction, thus insulin treatment is recommended in such cases. Women who are pregnant, possibly pregnant, or breastfeeding should also refrain from taking this medication, and it's recommended to switch to insulin therapy as needed. Patients with severe infections or those undergoing surgery, or those experiencing severe trauma should receive insulin therapy instead of this medication. Patients with gastrointestinal issues such as diarrhea or vomiting should be cautious due to the risk of hypoglycemia from poor food absorption. During the first week of treatment, the risk of hypoglycemia is higher, so blood glucose should be monitored closely, especially for the elderly, those in poor nutritional status, patients who skip or have irregular meals, and those who frequently consume alcohol. Patients with decreased renal or hepatic function, other concurrent conditions, or taking other medications should consult their physician as they may be at increased risk for hypoglycemia, and dosage adjustments may be necessary. Symptoms of hypoglycemia, such as headache, severe hunger, nausea, fatigue, confusion, dizziness, may occur, and if these symptoms arise, immediate intake of sugar and consultation with a physician is required. Furthermore, there may be changes in vision, gastrointestinal discomfort, liver dysfunction, blood abnormalities, allergic reactions, so any unusual symptoms should be reported to a healthcare professional immediately. This medication should be taken regularly and along with dietary and exercise regimens, and it’s advisable to always keep sugar on hand to reduce the likelihood of hypoglycemic episodes. Co-administration with other medications may affect blood glucose control, so if starting or stopping any medications, healthcare professionals should be informed. Pregnant or breastfeeding women should avoid this medication and switch to insulin therapy, and the safety and efficacy in children under 18 years have not been established. Elderly patients should be cautious in adjusting the dosage considering renal function. In cases of overdose, hypoglycemia can be severe, so immediate medical attention is needed for appropriate treatment, which may include induced vomiting, gastric lavage, or intravenous dextrose.

Serious side effects

Hives, severe swelling (edema), tightness in chest, difficulty breathing, cold sweat, paleness, severe rash with high fever, blisters, skin peeling, pain in mucous membranes of mouth/eyes, difficulty breathing or shortness of breath, asthma attack, respiratory abnormalities with cough and fever, yellowing of skin or eyes (jaundice), extreme lethargy, sudden severe headache, thunderclap headache, seizures, confusion, vision abnormalities, paralysis, urination issues.

Mild side effects

Headache, severe hunger, nausea, vomiting, fatigue, sleep disturbances, anxiety, aggression, decreased concentration, decreased agility or activity, depression, confusion, abnormal speech, aphasia, visual disturbances, tremors, incomplete paralysis, sensory disturbances, dizziness, weakness, loss of self-control, transient mental confusion, drowsiness, bradycardia, sweating, cold and moist skin, tachycardia, hypertension, palpitations, angina pectoris, arrhythmia, blurred vision, sensation of fullness or pressure in the upper abdomen.

This medication may be sensitive to air or moisture, so it should be stored in a tightly sealed container. The recommended storage temperature is between 1 and 30 degrees Celsius.

Appearance

Green elongated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle