Medication info
Diphion Tablet (Diethylpropion Hydrochloride)

Diphion Tablet (Diethylpropion Hydrochloride)

Prescription medicationTabletOral
Ingredient · strength
Diethylpropion Hydrochloride›25mg / 1 tablet
Manufacturer / importer
Bionex Co., Ltd.
Appearance
White rhomboid tablets
Packaging
30, 300 tablets/bottle
Approval status
Active

MFDS item code 200410825 · Approved 2004.07.29

Summary

Main use
Short-term adjunctive treatment for weight loss in patients with obesity
Who takes it
Adults
Adult dose
Adults: Administer 25 mg of diethylpropion hydrochloride orally 3 times daily, 1 hour before meals. The maximum daily dose is 75 mg. Take this medicine no later than 4 hours before bedtime. To minimize the potential for abuse, prescribe or dispense the lowest possible dose during initial treatment (within 2 weeks), adjusting the dose individually to achieve an adequate response. This medicine should be administered for a short term (within 4 weeks). However, to reduce the risk of inappropriate use, treatment may be continued if the patient achieves satisfactory weight loss within the first 4 weeks (at least 1.8 kg of weight loss, or weight loss considered satisfactory by both the physician and patient).

Ingredients

Manufacturer
Bionex Co., Ltd.

Efficacy & effects

Short-term adjunctive treatment for weight loss in patients with obesity

  • Obesity
  • hypertension
  • diabetes
  • hyperlipidemia
View approved original text

This medication is a short-term adjunctive treatment for weight loss in obese patients with a body mass index (BMI) of 30 or higher who do not respond to proper diet and exercise, or for those with a BMI of 27 or higher who have risk factors such as hypertension, diabetes, or hyperlipidemia. Patients should use this medication in conjunction with a weight loss regimen based on caloric restriction. Please remember that this medication should be used alone and not in combination with other appetite suppressants. The body mass index is calculated by dividing the patient's weight (kg) by the square of height (m), which is used to determine obesity. This medication is effectively utilized for the health enhancement and weight loss of obese patients who struggle to control their weight.

How to take

Adult dose

Adults: Administer 25 mg of diethylpropion hydrochloride orally 3 times daily, 1 hour before meals. The maximum daily dose is 75 mg. Take this medicine no later than 4 hours before bedtime. To minimize the potential for abuse, prescribe or dispense the lowest possible dose during initial treatment (within 2 weeks), adjusting the dose individually to achieve an adequate response. This medicine should be administered for a short term (within 4 weeks). However, to reduce the risk of inappropriate use, treatment may be continued if the patient achieves satisfactory weight loss within the first 4 weeks (at least 1.8 kg of weight loss, or weight loss considered satisfactory by both the physician and patient).

Precautions

This medication should not be used in combination with other appetite suppressants and should only be used alone for a short period. It is not recommended to combine with other medications for weight loss, as safety and efficacy have not been established. The weight loss effect of this medication is limited, and tolerance may develop after a certain period, so do not increase the dosage and stop using it. Long-term use may lead to drug abuse and dependence, so it must be managed strictly. If psychological dependence occurs, the dosage should be gradually reduced before discontinuation, as abrupt discontinuation may result in severe fatigue and depression. If symptoms such as angina, syncope, peripheral edema, or shortness of breath during exercise occur, stop taking the medication immediately and check for pulmonary hypertension. This medication may increase the risk of rare but fatal pulmonary hypertension, so caution is required. There are risks associated with heart valve disease, so it is advisable to undergo cardiac examinations before and during treatment. This medication should not be used in patients with certain conditions or those taking specific medications. Caution should be exercised for patients with cardiovascular disease, hypertension, epilepsy, diabetes, etc., and regular monitoring is necessary. Side effects may include insomnia, irritability, dizziness, anxiety, dry mouth, rapid heartbeat, epigastric pain, arrhythmias, palpitations, elevated blood pressure, changes in electrocardiograms, exercise abnormalities, blurred vision, hyperexcitability, restlessness, unusual euphoria, discomfort, depression, tremors, dilated pupils, drowsiness, fatigue, headaches, diarrhea, constipation, nausea, vomiting, abdominal discomfort, unpleasant taste, xerostomia, stomatitis, other gastrointestinal disorders, erectile dysfunction, dysmenorrhea, changes in libido, menstrual pain. In case of overdose, severe toxic symptoms and cardiovascular abnormalities may appear, so immediate medical attention should be sought. It is advisable for pregnant or nursing women not to use this medication, especially during early pregnancy. The use of this medication is not recommended for children and the elderly. Since this medication affects the central nervous system, caution should be taken when driving or operating dangerous machinery. This medication can interact with other medications, so it is essential to inform healthcare professionals of any other medications being taken. This medication is classified as a schedule drug, with potential for abuse and dependence, so it should be strictly used under a doctor's guidance. Store out of reach of children and in a sealed container.

Side effects

  • Insomnia
  • irritability
  • dizziness
  • anxiety
  • restlessness
  • thirst
  • tachycardia
  • epigastric pain
  • arrhythmia
  • palpitations
Show 69 more
  • increased blood pressure
  • changes in electrocardiogram
  • primary pulmonary hypertension
  • valvular heart disease
  • exercise intolerance
  • blurred vision
  • over-excitability
  • agitation
  • altered state of consciousness
  • discomfort
  • depression
  • tremors
  • pupil dilation
  • drowsiness
  • lethargy
  • headache
  • cerebrovascular accident
  • psychotic episodes
  • increased convulsive disorders
  • diarrhea
  • constipation
  • nausea
  • vomiting
  • abdominal discomfort
  • abdominal pain
  • unpleasant taste
  • dry mouth
  • stomatitis
  • urticaria
  • rash
  • petechiae
  • erythema
  • erectile dysfunction
  • dysmenorrhea
  • changes in libido
  • menstrual difficulties
  • gynecomastia
  • bone marrow suppression
  • leukopenia
  • agranulocytosis
  • thrombocytopenia
  • dyspnea
  • hair loss
  • myalgia
  • urination disorders
  • polyuria
  • sweating
  • vascular edema
  • agitation
  • tremors
  • hyperreflexia
  • hypersensitivity
  • rapid breathing
  • confusion
  • aggression
  • hallucinations
  • panic state
  • frequent seizures
  • exhaustion
  • drowsiness
  • fatigue
  • coma
  • changes in blood pressure
  • vascular collapse
  • abdominal cramps
  • severe skin disease
  • hyperfunction
  • changes in personality
  • schizophrenia-like mental disorders

Not everyone experiences these, and they can vary from person to person.

Storage

This medication should be stored in an air-tight container and kept at room temperature, between 1 degree Celsius and 30 degrees Celsius. Storing it this way can help maintain the medication's effectiveness for a longer period.

Appearance and packaging

Appearance

White rhomboid tablets

Package unit

30, 300 tablets/bottle

Same-ingredient medicines

Even with the same ingredient, strength, dosage form and how it is taken can differ.

Even with the same ingredient, the dose and directions can differ by strength and dosage form. Talk to a doctor or pharmacist before switching from a medication you are already taking.

Questions about this medicine

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This drug information is based on data provided by the Korea Ministry of Food and Drug Safety.
Consult a doctor or pharmacist for accurate dosage, administration, and usage instructions.