Rokpenal Tablets (Loxoprofen Sodium Hydrate)

Adult dose

1. For efficacy/effect 1 and 2: Adults should take Loxoprofen Sodium (anhydrous) 60 mg orally three times a day. For single therapy, 60-120 mg should be taken orally at once. 2. For efficacy/effect 3: Adults should take Loxoprofen Sodium (anhydrous) 60 mg orally. In principle, it can be taken twice a day, with a maximum daily dose of 180 mg. It is advisable to avoid taking it on an empty stomach.

This medication poses a risk of gastrointestinal bleeding if taken by individuals who regularly consume three or more drinks a day; therefore, it is essential to consult a doctor or pharmacist. Non-steroidal anti-inflammatory drugs including this medication may increase the risk of cardiovascular disease, which could lead to serious issues like myocardial infarction or stroke. Even in individuals without a history of cardiovascular disease, careful monitoring of symptoms is essential, and any unusual symptoms should be reported to medical personnel immediately. This medication may cause severe gastrointestinal side effects such as gastrointestinal bleeding, ulcers, and perforation, particularly in the elderly or those with a history of gastrointestinal disorders. The risk increases with prolonged use, so gastrointestinal symptoms should be closely monitored. Patients with a history of peptic ulcer, severe blood disorders, liver dysfunction, kidney disorders, or heart failure, as well as those who are hypersensitive to this medication, should not take it. Additionally, individuals with allergic reactions to aspirin or other non-steroidal anti-inflammatory medications, pregnant women in late pregnancy, and breastfeeding mothers should not use this medication. Patients with a history of peptic ulcers, blood, liver, or kidney disorders, the elderly, and those with hypertension should use this medication cautiously, and their condition should be closely monitored during treatment. If rash, hives, difficulty breathing, or blood pressure drop occur while taking this medication, stop taking it immediately and seek medical attention. This medication can cause various side effects such as gastrointestinal bleeding, liver dysfunction, kidney impairment, and skin reactions, so any unusual symptoms should be reported to medical personnel immediately. Combining this medication with other non-steroidal anti-inflammatory drugs may increase the risk of side effects; therefore, it is advisable not to do so. This medication may also interact with various drugs, so it is crucial to inform the doctor or pharmacist about any other medications currently being taken. It should only be administered at the minimum dosage during the first and second trimesters of pregnancy and must absolutely not be taken during late pregnancy due to the risk to the fetus. It is also recommended not to use this medication while breastfeeding. Safety for use in pediatric patients has not been established, so it is advisable not to use this medication in children. Particular caution is necessary when administering this medication to the elderly due to the higher risk of side effects. This medication should be stored out of the reach of children and should not be transferred to other containers to ensure safety and quality maintenance.

Serious side effects

Hives, severe swelling (including angioedema and facial swelling), tightness in the chest, difficulty breathing, shock, anaphylaxis-like symptoms, peptic ulcer, intestinal perforation, hematemesis, melena, bloody stools, severe skin reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis, mucocutaneous syndrome, erythema multiforme, acute generalized exanthematous pustulosis, DRESS syndrome), asthma attacks, shortness of breath, liver dysfunction (including jaundice), fulminant hepatitis.

Mild side effects

• Rash
• itching
• fever
• abdominal pain
• discomfort in the upper abdomen
• loss of appetite
• nausea
• vomiting
• diarrhea
• constipation

This medication may be sensitive to air or moisture, so it must be stored in a tightly sealed container. The storage temperature should be kept between 1 and 30 degrees Celsius at room temperature to maintain its effectiveness over time.

Appearance

White to Yellowish Round Tablets

Package unit

30 Tablets/Bottle, 300 Tablets/Bottle