Agapurine Injection (Pentoxifylline)

Adult dosage

1. Intravenous injection: For adults, inject 100mg of pentoxifylline daily. Have the patient lie down and administer the intravenous injection slowly over at least 5 minutes. To assess the patient's individual response, it is preferable to dilute the initial dose in physiological saline for injection. 2. Intravenous infusion: Initially, mix 100mg daily with 250~500ml of infusion solution (e.g., physiological saline for injection, 5% fructose injection) and administer by intravenous infusion over 90~180 minutes. Starting the following day, increase the dose by 50mg daily until the daily dose reaches 300mg. In cases of severe circulatory disorders, administer twice daily. 3. As adjunctive therapy to intravenous injection or intravenous infusion, 100~200mg of the tablet may be administered. After symptoms improve, treatment may be continued by oral administration. Adjust the dose as appropriate according to age and symptoms.

This medication is in injection form, so care must be taken when opening the glass ampoule to prevent glass fragments from entering. Particularly, extra caution should be exercised when administering it to children and the elderly. This medication should not be used in certain patients. For example, individuals who are allergic to this medication or similar class drugs, patients with acute myocardial infarction, those with severe bleeding, patients with bleeding in the eyes, and those taking another medication called Ketorolac should not use this medication. Furthermore, individuals with heart rhythm problems or low blood pressure, those with severely impaired kidney or liver function, patients at high risk for bleeding, and those with serious vascular diseases should use this medication with extreme caution. Using this medication may cause allergic symptoms such as skin itching, redness, hives, and in severe cases, serious reactions like breathing difficulties or shock may occur. If such symptoms appear, immediately discontinue the medication and consult a physician. Cardiac-related side effects such as rapid heartbeat, chest pain, and low blood pressure may rarely occur. Liver function abnormalities may also arise, and the medication may affect blood coagulation, increasing the risk of bleeding. Neurological symptoms such as dizziness, headache, anxiety, and sleep disturbances may occasionally occur. Administering this medication in high doses quickly can increase the occurrence of problems such as fever, gastrointestinal discomfort, nausea, vomiting, diarrhea, and arrhythmia. Patients with low blood pressure or unstable blood circulation should start with a small amount and gradually increase the dosage, while heart failure patients should use it alongside appropriate treatments. Using this medication with anticoagulants can increase the risk of bleeding, and it can enhance the effects of diabetes medications, so careful blood sugar management is necessary. Additionally, when used with other blood pressure-lowering medications, the hypotensive effect may be more pronounced. Particularly, using it with a medication called Theophylline can increase its concentration, leading to more severe side effects, so caution is needed. It should not be used with Ketorolac. It is safest for pregnant or breastfeeding women not to use this medication. There is a lack of experience using this medication in children, so it is not recommended for pediatric use. Elderly patients may have reduced physical function, so careful observation is required when administering this medication.

• pruritus
• skin redness
• urticaria
• angioedema
• bronchospasm
• shock
• tachycardia
• angina
• anginal pain
• hypotension

This medication is sensitive to light, so it should be stored in a light-protected, tightly sealed container. Additionally, storing the medication at room temperature between 1 and 30 degrees Celsius is safe. Proper storage will help maintain the medication's effectiveness for a longer period.

Appearance

A brown ampoule containing a colorless liquid injection.

Package unit

5mL/ampoule X 10