Glimepiride Tablet 2 mg (Glimepiride)

Adult dose

Administer orally once daily. In patients who have not previously received medication, initial dosing starts with 1 mg of Glimepiride once daily. If necessary, increase by 1 mg at weekly intervals. Generally, additional effects are minimal at doses above 4 mg; however, some patients may increase to 6 mg (or 8 mg). The typical maximum daily dose is 4 mg.

This medication should not be administered to patients with insulin-dependent diabetes or those in a diabetic coma. Patients who have had allergic reactions to this medication, sulfonylureas, or sulfonamide medications should avoid its use. There is no prior experience with its use in patients with severe liver or kidney dysfunction; thus, transitioning to insulin therapy is advised for such cases. Women who are pregnant or may become pregnant, as well as breastfeeding women, should not take this medication. For patients with severe infections, pre- or post-surgical conditions, or severe trauma, insulin therapy is recommended. Patients with gastrointestinal disorders should be cautious, as issues with food absorption could increase the risk of hypoglycemia. This medication contains lactose and should not be given to patients with genetic metabolic disorders such as galactose intolerance. During the initial dosing, the risk of hypoglycemia is high, hence special caution is warranted, especially in elderly patients, those with poor nutritional status, and those with irregular meal patterns. Patients who consume alcohol or have impaired liver and kidney function may also have an increased risk of hypoglycemia. Furthermore, careful monitoring is necessary for those with thyroid or adrenal dysfunction, and in cases of overdose, the risk of hypoglycemia is elevated. Patients who have allergic reactions to Yellow No. 4 (Tartrazine) should use this medication cautiously. It is essential to understand the symptoms of hypoglycemia when taking this medication; if hypoglycemia occurs, sugary foods should be consumed immediately. Severe hypoglycemia may require medical treatment. Additionally, this medication lowers blood sugar levels, thus regular monitoring of blood sugar control is necessary, and if effects are insufficient, other treatment methods may need to be considered. Drug interactions should also be noted. Concurrent use with certain medications may increase or decrease the blood sugar-lowering effect; therefore, other medications must be disclosed to a physician or pharmacist. Special attention should be paid to changes in blood sugar when combined with beta-blockers, antibiotics, antifungals, and steroids. Pregnant or breastfeeding women should refrain from taking this medication; if necessary, transitioning to insulin therapy is safer. Elderly patients should be cautious regarding dosage adjustments due to common occurrences of decreased kidney function. In case of overdose, severe hypoglycemia may occur, requiring immediate medical attention, with possible emergency measures such as inducing vomiting, stomach flushing, or glucose injections. Lastly, the safety and efficacy of this medication have not been established in children, so it is advisable to avoid use in individuals under 18 years of age.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with fever, blisters, skin peeling, pain in mucous membranes of mouth/eyes, breathing difficulties, asthma attacks, coughing, abnormal respiratory signs accompanied by fever, yellowing of skin or eyes (jaundice), extreme lethargy, sudden and severe headaches, thunderclap headaches, seizures, confusion of consciousness, visual disturbances, paralysis, and significant reduction in urine output.

Mild side effects

• Headache
• severe hunger
• nausea
• vomiting
• fatigue
• drowsiness
• sleep disturbances
• anxiety
• aggression
• decreased concentration

This medication may be sensitive to air or moisture, thus it should be stored in a sealed container. The storage temperature should be maintained between 1 and 30 degrees Celsius at room temperature. Proper storage will safely preserve the medication's efficacy.

Appearance

Green snowman-shaped tablet

Package unit

30 tablets/bottle, 500 tablets/bottle