Hurofen Tablet (Sodium Loxoprofen Hydrate)

Adult dose

1. For efficacy and effect 1, 2: Adults should take 60 mg of loxoprofen sodium (anhydrous) by mouth three times a day. For a single treatment, 60-120 mg may be taken orally each time. 2. For efficacy and effect 3: Adults should take 60 mg of loxoprofen sodium (anhydrous) by mouth. In principle, it can be taken twice daily, with a maximum of 180 mg per day. It is preferable to avoid taking it on an empty stomach.

This drug should be used with caution in individuals who regularly consume more than three alcoholic beverages daily. Consultation with a doctor or pharmacist is necessary before use, as the risk of gastrointestinal bleeding may increase when taken with alcohol. This drug may pose risks to the cardiovascular system, potentially increasing the risk of serious thrombotic reactions such as myocardial infarction or stroke. Extra caution is warranted for individuals with cardiovascular diseases or risk factors. If cardiovascular symptoms occur during use, immediate medical consultation is required. It can also affect the gastrointestinal tract, leading to severe issues such as bleeding, ulcers, or perforation in the stomach or intestines. Such issues can occur irrespective of the duration of administration, so particular caution should be taken in individuals with a history of gastrointestinal disorders or the elderly. Patients with a history of peptic ulcer, severe blood disorders, liver impairment, kidney impairment, heart failure, or those allergic to any component of this drug should not use it. Additionally, it should not be administered to pregnant women in late pregnancy, nursing mothers, or patients with inflammatory bowel disease. Individuals with a past history of peptic ulcer or with blood, liver, or kidney diseases, elderly patients, hypertension, or asthma should exercise extra caution during use and closely monitor their condition according to a doctor's instructions. If hypersensitivity reactions such as skin rash, itching, or hives occur during use, discontinue the medication immediately, as severe cases may present with shock or anaphylaxis. Gastrointestinal symptoms may include abdominal pain, nausea, vomiting, diarrhea, and severe cases may lead to gastrointestinal bleeding or perforation, necessitating immediate medical consultation if symptoms develop. This drug may induce neurological symptoms such as drowsiness, dizziness, or headache, and can rarely cause anemia or liver and kidney function abnormalities, which may require regular monitoring. Concurrently taking this drug with other non-steroidal anti-inflammatory drugs increases the risk of side effects, therefore they should not be used together. Additionally, interactions may occur with blood glucose-lowering agents, antibiotics, diuretics, anticoagulants, lithium, methotrexate, etc., hence, it is essential to inform the healthcare provider about any medications currently being taken. It should not be used during pregnancy, particularly in the late stages, as it may pose risks to the fetus, and it is also advisable not to take it while breastfeeding. The safety of this medication in children has not been established, therefore it should not be administered to pediatrics. Elderly patients have a higher risk of side effects, thus special caution is needed during administration. This drug should be kept out of the reach of children and should not be transferred to another container as it may cause quality issues.

Serious side effects

Hives, severe swelling (edema), tightness in the chest, difficulty breathing, shock, anaphylaxis-like symptoms, peptic ulcer, hematemesis, melena, skin and mucous membrane syndrome (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome), acute generalized exanthematous pustulosis, jaundice of the skin and eyes, liver dysfunction (including jaundice), fulminant hepatitis, acute renal failure, difficulty breathing, asthma attacks, interstitial pneumonia, aseptic meningitis (fever)

Mild side effects

• Rash
• itching
• fever
• abdominal pain
• discomfort in the upper abdomen
• loss of appetite
• nausea
• vomiting
• diarrhea
• constipation

This drug should be stored in a tightly closed container to prevent exposure to air or moisture, ideally at room temperature between 1°C to 30°C. By storing it this way, the effectiveness of the drug can be maintained, and degradation can be prevented.

Appearance

Pink round tablet

Package unit

For domestic use - 30 tablets/bottle, For domestic use - 500 tablets/bottle, For export - 30 tablets/PTP [(10 tablets PTP x 3)]