Repira Tablet (Levospiride)

Adult dose

Adults: Administer 25 mg of levosulpiride orally 3 times daily before meals.

This medication should not be used in women who are pregnant or may become pregnant and in women who are breastfeeding. It should also not be administered to patients at risk for gastrointestinal bleeding or mechanical obstruction, perforation, etc., as it may stimulate gastrointestinal motility. It is contraindicated in patients with certain tumors like pheochromocytoma, as it may cause hypertension. Patients who are allergic to this medication or cannot tolerate it should not be given this drug. Patients with liver disease or in the manic phase of bipolar disorder should also avoid using this drug. Caution is needed in patients with malignant breast disease, as this medication may increase prolactin secretion, possibly leading to breast-related abnormalities. It should be administered cautiously in patients with hypertension, children, and elderly patients. In children, extrapyramidal symptoms may easily occur, thus dosage adjustments should be considered. During the course of treatment, endocrine symptoms such as amenorrhea, galactorrhea, or gynecomastia may occur, requiring monitoring of such symptoms; emediate discontinuation should occur if abnormalities arise. Moreover, extrapyramidal symptoms like tremors, tongue twisting, and restlessness may rarely occur, and discontinuation of medication should happen if such symptoms are observed. Long-term use may result in involuntary movements, and gastrointestinal symptoms such as dry mouth, heartburn, nausea, vomiting, diarrhea, and constipation may also be experienced. Cardiac side effects may include hypertension and arrhythmias, necessitating careful monitoring of cardiovascular health. A serious side effect known as Neuroleptic Malignant Syndrome has been reported, with symptoms such as high fever, muscle rigidity, and altered consciousness; prompt cessation of the drug and emergency treatment is required. Skin rashes, edema, flushing, lethargy, insomnia, drowsiness, dizziness, unsteadiness, erectile dysfunction may also occur rarely, so caution is advised. This medication requires caution when performing activities that require attention, such as driving or operating machinery. Interactions with other medications can occur, especially with anticholinergics, narcotic analgesics, digitalis preparations, benzamide drugs, psychiatric medications, alcohol, and when combined with drugs that prolong the QT interval, the risk of cardiac arrhythmias may increase. It is also safer to avoid taking it with drugs that may cause electrolyte imbalances. For pregnant and breastfeeding women, its safety for the fetus and neonate has not been established, so it should not be administered. Elderly patients may have decreased kidney function, which could prolong the drug's persistence in the body, requiring careful dose and interval adjustments and vigilance for adverse reactions. This medication has an antiemetic effect, which may mask vomiting symptoms caused by intoxication, intestinal obstruction, or brain tumors; thus, it should be used cautiously. Animal studies have reported testicular atrophy, decreased pregnancy rates, and increased tumorigenesis risk, necessitating caution in long-term high-dose use.

• Amenorrhea
• hyperprolactinemia
• gynecomastia
• tremors
• tongue twisting
• agitation
• involuntary movements around the mouth
• thirst
• heartburn
• nausea

This medication should be stored in a tightly sealed container to protect it from air and moisture, and it is advisable to keep it at room temperature between 1 and 30 degrees Celsius. Proper storage will effectively maintain the medication's efficacy.

Appearance

White circular tablet

Package unit

30 tablets, 300 tablets