Glimepide Tablet 1 mg (Glimiperide)

Adult dose

The initial dose is 1 mg of Glimepiride once daily. If necessary, the dosage may be increased by 1 mg at intervals of 1 to 2 weeks. Generally, doses greater than 4 mg provide little additional benefit, although some patients may require a dose increase to 6 mg (or 8 mg). If a daily dose of 4 mg fails, consider switching to insulin therapy or using insulin in combination with other oral diabetes medications.

This medication should not be used in patients with insulin-dependent diabetes or those in diabetic ketoacidosis or coma. Avoid use if there is an allergy to this medication, its components, or sulfonylureas. Since it contains lactose, it should not be administered to patients with galactose intolerance or lactose deficiency. Patients with severe liver or kidney impairment should not use this medication, and switching to insulin therapy is recommended. It is safest for women who are pregnant or may become pregnant, and for breastfeeding women, to avoid this medication. In cases of severe infection, before and after surgery, or in cases of severe trauma, insulin therapy is preferred. In the case of gastrointestinal disturbances such as diarrhea or vomiting, there is a risk of hypoglycemia due to inadequate food absorption and caution is advised. During the first week of administration, the risk of hypoglycemia is high, and blood sugar levels should be closely monitored, especially in the elderly, those with poor nutritional status, irregular eating patterns, or those who consume alcohol. Imbalances in muscle exercise and carbohydrate intake, as well as kidney and liver function impairments or endocrine diseases, can also increase the risk of hypoglycemia, so caution is advised. Additionally, when used in combination with other medications, there may be interactions that affect blood sugar control, so consultation with a doctor or pharmacist is essential. Patients allergic to Tartrazine (Yellow No. 5) should also use this medication cautiously. This medication can cause hypoglycemia, with symptoms including headache, severe hunger, nausea, fatigue, anxiety, confusion, drowsiness, and loss of consciousness. Hypoglycemia can be quickly addressed by consuming sugar, so patients are advised to always carry sugar with them. Initial treatment may lead to blurred vision, gastrointestinal symptoms, liver function abnormalities, blood abnormalities, or allergic reactions; if any concerning symptoms arise, the healthcare provider should be notified immediately. Severe allergic reactions or severe hypoglycemia can be life-threatening and require immediate medical attention. This medication should be taken in conjunction with a regular diet and exercise regimen, and blood sugar control should be routinely monitored. In particular, during stressful situations, surgery, or infections, blood sugar control may become more challenging, and switching to insulin therapy may be necessary. Additionally, caution is needed when driving or operating machinery while taking this medication. This medication can interact with other drugs, so patients must inform their healthcare provider of any other medications they are taking, especially when using CYP2C9-related drugs, beta-blockers, or alcohol. Pregnant or breastfeeding women should refrain from using this medication due to potential effects on the fetus and newborn, and insulin therapy should be considered as needed. The safety and efficacy in children under 18 years of age have not been established, and its use is not recommended. Elderly patients may have decreased kidney function, so careful dose adjustment is necessary. In the event of an overdose, hypoglycemic symptoms may appear, and immediate notification to a healthcare provider is necessary, and emergency measures such as gastric lavage or intravenous glucose may be required. This medication should be stored out of reach of children and kept in its original container for safety.

Serious side effects

Urticaria, severe swelling (edema), difficulty breathing, jaundice of the skin or eyes, liver function abnormalities, severe thrombocytopenia accompanied by thrombocytopenic purpura, anaphylaxis, angioedema, skin and mucous membrane syndrome (Stevens-Johnson syndrome), severe hypoglycemia, seizures, loss of consciousness, coma, shock, cholestasis, jaundice, hepatitis.

Mild side effects

• Headache
• severe hunger
• nausea
• vomiting
• fatigue
• sleep disturbances
• anxiety
• aggression
• decreased concentration
• reduced agility or motor activity

This medication should be stored in a tightly sealed container to protect it from air and moisture. It is recommended to store the medication at room temperature between 1°C and 30°C. Proper storage preserves the medication’s efficacy and safety.

Appearance

Pale pink oblong tablet

Package unit

30 tablets/bottle, 100 tablets/bottle