Amotin Tablets (Famotidine)

Adult dosage

For oral administration, 20 mg once, twice daily (after breakfast, after dinner, or at bedtime) or 40 mg once daily (at bedtime). Alternatively, 10 mg once, twice daily (after breakfast, after dinner, or at bedtime) or 20 mg once daily (at bedtime) may be administered. For injectable forms, dissolve 20 mg in 20 mL of normal saline or dextrose solution.

This medication should not be used in patients who have experienced allergic reactions to its components or other H2 receptor antagonists. Also, since it contains lactose, it should not be administered to patients with genetically determined lactose degradation disorders. Patients with drug allergies, impaired renal function, heart diseases, impaired liver function, and the elderly should use this medication with caution. Patients with impaired kidney function may experience elevated blood drug concentration, so the dosage should be adjusted or the dosing interval extended. Serious side effects such as allergic reactions, blood abnormalities, severe skin diseases, liver dysfunction, muscle abnormalities, heart arrhythmias, changes in consciousness, kidney problems, and pneumonia may occur during the use of this medication, so careful observation is required. If any adverse reactions occur, the medication should be discontinued immediately, and medical advice should be sought. During treatment, regular blood tests and liver and kidney function tests should be conducted. This medication dissolves in the mouth but is not absorbed through the oral mucosa, so it must be swallowed with saliva or water. If a patient undergoing hemodialysis uses this medication along with specific phosphate binders, the drug's efficacy may decrease, so caution is needed. This medication may also affect drug concentrations and efficacy when taken with certain antifungal and specific anticancer drugs, so consulting a physician is necessary. Elderly patients may require dosage adjustments due to elevated drug concentrations stemming from impaired renal function. Women who are pregnant or may become pregnant should only use this medication if the benefits outweigh the risks, as its safety during pregnancy is not confirmed. Breastfeeding women should discontinue breastfeeding as this medication can be passed into breast milk. The safety for pediatric patients has not been sufficiently established, so caution should be exercised in use. Finally, this medication may mask symptoms of gastric cancer, so it should only be used when it is definitely not gastric cancer.

Serious side effects

Hives, severe swelling (facial edema, pharyngeal edema, etc.), shock, hypersensitivity reactions (anaphylaxis, respiratory distress, generalized flushing, angioedema), Stevens-Johnson syndrome, Lyell's syndrome, liver dysfunction, jaundice, rhabdomyolysis, QT prolongation, ventricular tachycardia, ventricular fibrillation, altered consciousness, seizures, interstitial nephritis, acute renal failure, interstitial pneumonia, congestive heart failure

Mild side effects

• Constipation
• diarrhea
• dry mouth
• nausea
• vomiting
• abdominal distension
• loss of appetite
• stomatitis
• increased blood pressure
• facial flushing

This medication should be stored in a tightly closed container to prevent air or moisture from entering. It is recommended to maintain the storage temperature between 1 to 30 degrees Celsius at room temperature.

Appearance

White round film-coated tablets

Package unit

30 tablets/bottle, 200 tablets/bottle