Penrex Tablet (Loxoprofen Sodium Hydrate)

Adult dose

1. For indications 1 and 2: Adults: Administer 60 mg of Loxoprofen Sodium (as anhydrous) orally three times a day. For a single dose regimen, administer 60-120 mg orally. 2. For indication 3: Adults: Administer 60 mg of Loxoprofen Sodium (as anhydrous) orally. In principle, it can be administered twice a day, with a maximum of 180 mg per day. Avoid taking on an empty stomach.

This medication should be used with caution in individuals who regularly consume more than three glasses of alcohol per day, as it may increase the risk of gastrointestinal bleeding. This drug may affect the cardiovascular system, potentially increasing the risk of serious cardiovascular conditions such as myocardial infarction or stroke. Patients with cardiovascular diseases or risk factors should be particularly cautious, and the emergence of cardiovascular symptoms should be closely monitored in consultation with a physician. Additionally, this medication can increase the risk of gastrointestinal bleeding, ulcers, and perforations, which can occur asymptomatically; therefore, elderly patients or those with a history of gastrointestinal disorders should use it with caution. Patients with a history of peptic ulcers, severe blood disorders, liver impairment, kidney impairment, heart failure, those with hypersensitivity to any ingredient in this medication, late-stage pregnant women, nursing mothers, and patients with inflammatory bowel disease should not take this medication. Patients with a history of peptic ulcers or diseases of the blood, liver, or kidneys, elderly patients, patients with hypertension, asthma, etc., should use this medication cautiously and monitor their condition closely during use. Various adverse reactions, including rash, itching, shortness of breath, abdominal pain, nausea, vomiting, diarrhea, constipation, chest tightness, dyspepsia, stomatitis, dryness of the mouth, abdominal distention, drowsiness, numbness, dizziness, headache, anemia, eosinophilia, hematuria, proteinuria, edema, chest pain, anxiety, fatigue, palpitations, fever, resolution, abnormal chest X-ray, eosinophilia, nausea, vomiting, abdominal distention, systemic lupus erythematosus (SLE) and mixed connective tissue disease, may occur; if these symptoms occur, stop taking the medication immediately and consult a healthcare professional. This medication may increase the risk of side effects when used in conjunction with other non-steroidal anti-inflammatory drugs, so it is advisable not to take them together. Furthermore, it may interact with blood pressure medications, diuretics, anticoagulants, antibiotics, lithium, methotrexate, etc.; therefore, inform your healthcare provider if you are taking these medications. During pregnancy, especially late-stage, it may be dangerous for the fetus and should be avoided, and it is also safer not to use this medication during breastfeeding. The safety of this medication in children has not been established; therefore, it should be administered cautiously in children, and elderly patients are at higher risk for side effects, so caution is necessary. This medication should be used at the minimum effective dose for the shortest duration necessary, and patient conditions should be closely monitored before and after administration. Finally, this medication must be stored out of the reach of children, and transferring it to another container can be detrimental to quality.

Serious side effects

Hives, severe swelling (including angioedema and facial swelling), chest tightness, difficulty breathing, shock, symptoms resembling anaphylaxis, gastrointestinal bleeding (hematemesis, melena, hematochezia), gastrointestinal ulcers, intestinal perforation, asthma attacks, skin and mucosal syndrome (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell syndrome), acute generalized exanthematous pustulosis, liver dysfunction (including jaundice), acute kidney failure, interstitial nephritis, difficulty breathing, interstitial pneumonia.

Mild side effects

Occasionally, rash, itching, fever, abdominal pain, discomfort in the upper stomach, loss of appetite, nausea, vomiting, diarrhea, constipation, chest tightness, dyspepsia, stomatitis, dryness of the mouth, abdominal distention, drowsiness, numbness, dizziness, headache, anemia, eosinophilia, hematuria, proteinuria, edema, chest pain, anxiety, fatigue, palpitations, fever, resolution, abnormal chest X-ray, eosinophilia, nausea, vomiting, abdominal distention, systemic lupus erythematosus (SLE) and mixed connective tissue disease may occur.

This medication may be sensitive to air and moisture, so it should be stored in a tightly closed container. It is best stored at room temperature, between 1 to 30 degrees Celsius. Avoid very hot or very cold places.

Appearance

Pink round tablet

Package unit

30 tablets/bottle, 300 tablets/bottle