Carmen Tablet 10 mg (Carbimazole)

Adult dose

1. Adults 1) Initial dose: Administer 20 ∼ 60 mg orally per day and continue treatment until thyroid function becomes normal. 2) Subsequent treatment (1) Maintenance therapy: Adjust the dose as appropriate to maintain normal thyroid function, with a final dose of 5 ∼ 15 mg per day. Continue treatment for at least 6 months to 18 months. Ongoing monitoring of thyroid function is recommended, with appropriate dose changes as needed to maintain a euthyroid state. (2) Block-and-replace therapy: Maintain a dose of 20 ∼ 60 mg per day and administer iodothyronine concomitantly at 50 ∼ 150 μg per day to prevent hypothyroidism. Continue treatment for at least 6 months to 18 months. 3. Elderly patients: Although no special dosage regimen is required, the risk of potentially fatal outcomes such as neutropenia is higher in elderly patients (65 years and older); therefore, use with caution, taking the precautions for use into consideration.

Child dose

2. Children: The usual initial dose is 15 mg per day.

This medication should not be used in certain patients. For example, individuals who are allergic to this drug or its components, patients with thyroid cancer, those with severe blood disorders or significantly impaired liver function, and breastfeeding individuals should not take this medication. Patients with liver or kidney disease, or those with large goiters that compress the trachea should use this medication cautiously. While taking this medication, mild side effects such as nausea, headache, skin rash, and joint pain may occur during the initial 8 weeks of treatment, but it is usually acceptable to continue the treatment. However, if severe blood abnormalities, liver function issues, or conditions such as acute pancreatitis occur, stop taking the drug immediately and consult a physician. Especially, if sore throat, fever, bleeding, or symptoms of infection appear, it may indicate agranulocytosis, a serious blood disorder, and immediate medical attention is required. During pregnancy, taking this medication may affect the fetus, therefore, women of childbearing potential should use effective contraception during treatment, and if used during pregnancy, the dosage should be minimized, closely monitoring the fetus and newborn. This medication can interact with other drugs; caution is particularly needed when used with anticoagulants or certain thyroid medications. Additionally, this medication should be kept out of reach of children, and transferring it to another container may affect its quality, thus should be avoided. Regular blood tests and liver function tests should be conducted while on treatment, and any unusual symptoms should be reported to healthcare professionals immediately for safe management.

• Nausea
• headache
• mild indigestion
• skin rash
• joint pain
• itching
• hair loss
• bone marrow suppression
• agranulocytosis
• hypoprothrombinemia

This medication must be stored in a tightly closed container to prevent exposure to air or moisture. It is important to maintain a storage temperature between 1 degree and 30 degrees Celsius. Proper storage helps to maintain the efficacy and safety of the medication.

Appearance

Yellow rectangular film-coated tablet

Package unit

Domestic use - 300 tablets/bottle, Domestic use - 90 tablets/bottle, Export use - 100 tablets/box [(10 tablets/PTP×10)], Export use - 100 tablets/bottle