Cobis Tablet 2.5/6.25 mg

Adult dose

The initial dose is bisoprolol fumarate/hydrochlorothiazide 2.5/6.25 mg taken once daily. The dosage may be adjusted based on the patient’s response at 14-day intervals, with a maximum daily dose of bisoprolol fumarate/hydrochlorothiazide up to 20/12.5 mg. When discontinuing treatment, the dosage should be gradually reduced over a period of more than 2 weeks according to the patient's condition.

Child dose

No experience in use.

This medication is generally not administered to patients with bronchospastic lung disease. However, due to its high beta-1 selectivity, it may be used with caution in patients unresponsive to other treatments. When using this medication, it is important to start at the lowest possible dose and always administer a bronchodilator concomitantly. Patients with allergies or psoriasis should use this medication cautiously as it may cause hypersensitivity reactions. Patients with hyperthyroidism may experience masked symptoms with this medication, and sudden discontinuation may worsen symptoms, so gradual tapering is important. This medication should not be suddenly stopped, and when discontinuing, the dose should be gradually reduced according to the physician's instructions. This medication should not be used in patients with hypersensitivity to it or those with specific heart conditions, severe hypotension, congestive heart failure, pulmonary disease, pregnant women, or children. Especially, pregnant women or those who may become pregnant should not take this medication, and nursing mothers should avoid it or stop breastfeeding. Elderly patients or those with impaired liver or kidney function should start at a low dose and be monitored closely during treatment. This medication may interact with multiple other medications, so it is essential to inform the physician or pharmacist if taking other drugs. Long-term use should involve regular checks to monitor heart function, blood pressure, blood tests, etc., to ensure no abnormalities occur. Adverse reactions such as bradycardia, hypotension, shortness of breath, skin rash, dyspepsia, dizziness, fatigue, and others may occur, and if symptoms are severe, immediate consultation with healthcare professionals is needed. In case of overdose, severe bradycardia, hypotension, bronchospasm, heart failure, hypoglycemia may occur, and emergency treatment should be sought immediately.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweats, pallor (severe allergic reaction), severe rash with fever, blisters, skin peeling, pain in oral/ocular mucosa (severe skin adverse reaction), shortness of breath or difficulty breathing, asthma attack, cough with fever alongside respiratory abnormalities, yellowing of skin or eyes (jaundice), extreme lethargy (liver abnormalities), sudden and very severe reactions

Mild side effects

• Bradycardia
• increased heart size
• atrioventricular block
• hypotension
• palpitations
• heart failure
• atrial fibrillation
• chest pain
• intermittent claudication
• worsening of Raynaud's disease

This medication should be stored in a tightly sealed container to avoid air or moisture. The recommended storage temperature is between 1 and 30 degrees Celsius. This helps to maintain the effectiveness of the medication for longer.

Appearance

Yellow round film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle