Anataksim (Naproxen Sodium)

Adult dose

1. Rheumatoid arthritis, osteoarthritis, ankylosing spondylitis: administer 275-550 mg orally once, twice a day (every 12 hours). 2. Acute gout: give 825 mg orally as a loading dose, then administer 275 mg orally every 8 hours until the attack subsides. 3. Skeletal muscle disorders, postoperative pain, post-extraction pain, dysmenorrhea, tendinitis, bursitis: administer 550 mg orally as a loading dose, then 275 mg every 6-8 hours afterwards.

Persons who regularly consume more than three alcoholic drinks per day should consult a physician or pharmacist before taking this medication, as it increases the risk of gastrointestinal bleeding. Individuals with cardiovascular diseases or risk factors should be cautious, as there is a risk of cardiovascular issues such as myocardial infarction or stroke while taking this medication. This medication can cause serious adverse reactions such as gastrointestinal bleeding, ulcers, and perforations, and special care is needed for the elderly or those with a history of gastrointestinal diseases. Patients with a history of peptic ulcers, severe liver or kidney impairment, heart failure, hypertension, or blood disorders should not take this medication. Those with hypersensitivity or a history of allergic reactions to aspirin and other non-steroidal anti-inflammatory drugs should also avoid this medication. Patients with a history of peptic ulcers or bleeding tendencies and those with poor liver or kidney function should take this medication with caution and may require regular examinations under medical supervision. Rarely, this medication may cause various side effects such as shortness of breath, lowered blood pressure, skin rashes, gastrointestinal bleeding, hepatitis, kidney impairment, headaches, drowsiness, skin rashes, etc. If any abnormal symptoms occur, the medication should be discontinued immediately and medical attention sought. During pregnancy, especially in the late term, this medication should be avoided. After mid-pregnancy, it should only be used for the shortest duration at the minimum effective dose, as it may affect fetal kidney function. Breastfeeding women are advised not to take this medication, as it may be transmitted through breast milk and harm the baby. Safety has not been established for young children, particularly infants under the age of two, so use is not recommended. Elderly patients are at increased risk of gastrointestinal bleeding, so treatment should begin at lower doses and be administered cautiously, with close monitoring for adverse reactions. This medication may interact with other non-steroidal anti-inflammatory drugs, certain antihypertensive medications, diuretics, anticoagulants, etc., so inform healthcare providers of any concurrent medications. Overdose may lead to symptoms such as drowsiness, indigestion, and vomiting; in such cases, immediate medical treatment is necessary. This medication should be stored out of the reach of children, and transferring it to another container can compromise its quality, so caution is required.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, wheezing, respiratory distress, anaphylactic reactions, hematemesis, gastrointestinal bleeding, peptic ulcers, perforations, jaundice, severe liver dysfunction, severe headaches, confusion, seizures, vision disturbances, paralysis, aseptic meningitis, severe swelling, elevated blood pressure, impaired platelet function (prolonged bleeding time), Stevens-Johnson syndrome, epidermal necrolysis, exfoliative dermatitis, toxic epidermal necrolysis.

Mild side effects

• Hives
• rashes
• itching
• stomach discomfort
• stomach pain
• abdominal pain
• nausea
• vomiting
• loss of appetite
• indigestion

Drug interactions

This medication should not be taken with other non-steroidal anti-inflammatory drugs, naproxen derivatives, aspirin, or high doses of methotrexate. It is contraindicated with phenytoin-based anticonvulsants, sulfa drugs, sulfonylurea hypoglycemics, propranolol and other beta-blockers, ACE inhibitors, loop and thiazide diuretics, probenecid, lithium, low-dose methotrexate, coumarin anticoagulants, zidovudine, and fluoroquinolone antibiotics.

This medication should be stored in a tightly sealed container to protect it from air and moisture. It is best to maintain a storage temperature between 1 degree and 30 degrees Celsius.

Appearance

Light blue oval film-coated tablet

Package unit

10 tablets/PTP