Roxphenin Tablet (Loxoprofen Sodium Hydrate)

Adult dose

1. For indications 1 and 2: ○ Adults: Loxoprofen Sodium (anhydrous) 60 mg is to be taken orally three times a day. When taken as a single dose, 60 to 120 mg should be taken orally. 2. For indication 3: ○ Adults: Loxoprofen Sodium (anhydrous) 60 mg is taken orally. In principle, it can be taken twice a day, with a maximum daily dose of 180 mg. It is advisable to avoid taking it on an empty stomach.

This medication may cause gastric bleeding if taken by individuals who regularly consume more than three glasses of alcohol daily; therefore, it is essential to consult a physician or pharmacist. It contains a non-steroidal anti-inflammatory ingredient that may increase the risk of cardiovascular disease, so patients with heart disease or risk factors should exercise caution. Serious gastrointestinal side effects such as gastric bleeding, ulcers, and perforation may occur, so elderly patients or those with a history of gastrointestinal disease should be particularly careful. Patients with peptic ulcers, severe blood disorders, liver disorders, kidney disorders, or heart failure should not use this medication, and it should also be avoided in cases of hypersensitivity. Patients with a history of peptic ulcers or issues with liver or kidney function should be administered this medication cautiously, and their condition should be closely monitored during treatment. If any unusual symptoms such as rash, itching, shock symptoms, signs of gastrointestinal bleeding, or difficulty breathing occur while taking this medication, discontinue it immediately and consult healthcare personnel. Regular blood tests and liver and kidney function tests are required during long-term use, and if any abnormal symptoms are detected, treatment should be stopped or the dosage adjusted. Symptoms related to cardiovascular issues or gastrointestinal bleeding may appear, so these symptoms should be carefully monitored during treatment. Co-administration with other non-steroidal anti-inflammatory drugs should be avoided due to an increased risk of side effects, and there may be interactions with certain antihypertensives, anticoagulants, lithium, and methotrexate. During late pregnancy, this medication should not be taken as it may pose risks to the fetus; in early or mid-pregnancy, it should be used with utmost caution and only at the minimal effective dose as determined by a physician. It is safest not to use this medication while breastfeeding, and safety for use in pediatric patients has not been established, so special care is needed when administering it to children. Elderly patients are at higher risk for side effects and should be administered this medication with great caution; it should also be stored out of reach of children.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor → severe allergic reaction. Severe rash, blisters, skin peeling, pain in mouth/eye mucous membranes along with high fever → severe skin adverse reaction. Shortness of breath or difficulty breathing, asthma attack, respiratory problems accompanied by cough + fever → respiratory issues. Yellowing of the skin or eyes (jaundice), extreme lethargy → liver abnormalities (jaundice). Sudden and

Mild side effects

• Occasionally rash
• itching
• fever
• abdominal pain
• discomfort in the upper abdomen
• loss of appetite
• nausea
• vomiting
• diarrhea
• constipation

This medication should be stored in a tightly closed container to prevent exposure to air and moisture. Additionally, it is best to store the medication at room temperature between 1°C and 30°C, away from excessively hot or cold areas.

Appearance

White to slightly yellow circular tablets

Package unit

30 tablets/bottle, 300 tablets/bottle